Famotidin (famotidine) coated tablets 0.02 №10

Description

Famotidin tablets Storage
active substance: famotidine;

1 tablet contains famotidine 20 mg;

excipients: microcrystalline cellulose, lactose monohydrate, copovidone, croscarmellose sodium, magnesium stearate, colloidal anhydrous silica, azorubin (E 122); dry mixture “Opadry II white” containing titanium dioxide (E 171), talc, polyethylene glycol, polyvinyl alcohol.

Famotidin tablets Dosage form
Coated tablets.

Main physical and chemical properties: coated tablets, from pink to dark pink. In cross section, two layers are visible.

Famotidin tablets Pharmacotherapeutic group
Remedies for peptic ulcer and gastroesophageal reflux disease. H2-receptor antagonists. Famotidine. ATX code A02B A03.

Pharmacological properties
Pharmacodynamics. Famotidine is a selective antagonist of H2-histamine receptors of the III generation.

The mechanism of action is due to the competitive inhibition of H2-histamine receptors in the stomach wall, resulting in reduced secretion of gastric juice (its volume). Inhibits basal and stimulated production of hydrochloric acid and raises the pH of gastric juice. At the same time reduces the activity of pepsin.

Strengthens the protective mechanisms of the gastric mucosa by increasing the formation of gastric mucus and the content of glycoproteins in it, promotes healing of its damage (including scarring of stress ulcers).

After oral administration, the action begins in 1 hour, reaches a maximum within 3 hours and lasts, depending on the dose, 10-24 hours. The effect of famotidine at a dose of 20-40 mg lasts for 10-12 hours.

Pharmacokinetics. After oral administration, famotidine is rapidly absorbed in the digestive tract; concomitant food intake does not affect absorption. Cmax in blood plasma is reached in 1-3 hours. The binding to blood proteins is 15-20%. The relative bioavailability of famotidine is 40–45%. The state of gastric filling does not affect bioavailability. It enters the cerebrospinal fluid, the placental barrier and breast milk.

The drug is metabolized in the liver to form an inactive sulfoxide metabolite. Excreted mainly by the kidneys (65-70%) by glomerular filtration and tubular secretion; 25-30% of the received dose is removed in an unchanged form. T½ from blood plasma is approximately 3 hours.

In patients with severe renal insufficiency (creatinine clearance less than 10 ml / min) T½ is prolonged and may exceed 20 hours; in patients with anuria it is approximately 24 hours.

Indication
Benign gastric ulcer.
Peptic ulcer of the duodenum (treatment and prevention of recurrence).
Hypersecretory conditions, such as Zollinger-Ellison syndrome.
Treatment of gastroesophageal reflux disease (reflux esophagitis).
Prevention of symptoms and erosions or ulceration associated with gastroesophageal reflux disease.

Contraindication
Hypersensitivity to the components of the drug, other antagonists of H2-histamine receptors.

Childhood, pregnancy or breastfeeding (due to lack of necessary clinical experience).