Description

Finlepsin (carbamazepine) 400 tablets 400 mg. №50

Ingredients

Active ingredient: Carbamazepine 400mg per tablet.

Dosage

Recommended dosage: The usual starting dose is 200-400mg twice daily. Dosage may be adjusted based on individual response.

Indications

Indicated for: Epilepsy, trigeminal neuralgia, and bipolar disorder.

Contraindications

Do not use if: Hypersensitive to carbamazepine or tricyclic antidepressants.

Directions

– Take Finlepsin (carbamazepine) 400 tablets 400 mg orally with or without food.
– Swallow the tablets whole with a full glass of water.
– Do not crush or chew the tablets.

Scientific Evidence

Carbamazepine, the active ingredient in Finlepsin, works by stabilizing the electrical activity in the brain to control seizures and nerve pain. Studies have shown its efficacy in managing epilepsy and trigeminal neuralgia. Research published in the *Journal of Clinical Psychopharmacology* demonstrated the effectiveness of carbamazepine in treating bipolar disorder by reducing manic episodes.

Additional Information

It is important to monitor blood levels of carbamazepine regularly to ensure optimal dosage and minimize side effects. Common side effects may include dizziness, drowsiness, and nausea. Consult a healthcare provider for personalized recommendations.

Pharmacological Effects

Carbamazepine exerts its pharmacological action by blocking voltage-gated sodium channels, thereby stabilizing neuronal membranes and reducing excessive firing of neurons. This mechanism helps in controlling seizures and neuropathic pain associated with conditions like trigeminal neuralgia.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that carbamazepine is as effective as other antiepileptic drugs in the management of epilepsy. A study published in the *Journal of Neurology, Neurosurgery & Psychiatry* compared the effectiveness of carbamazepine with other anticonvulsants and found similar efficacy in seizure control with favorable tolerability profiles.

Investigating the pharmacokinetics and pharmacodynamics of carbamazepine against newer antiepileptic drugs can provide valuable insights into its comparative effectiveness and guide treatment decisions for patients with epilepsy and other neurological disorders.