Description
Fluorouracil (Fluorouracil) Solution for Injections 50 mg/ml. 20 ml. №1 Vial
Ingredients:
Fluorouracil (fluorouracil) solution for injections contains 50 mg/ml of the active ingredient fluorouracil.
Mechanism of Action:
Fluorouracil acts as an antimetabolite by inhibiting thymidylate synthase, thereby disrupting DNA synthesis in cancer cells. This mechanism leads to cell death and regression of tumors.
Pharmacological Properties:
Fluorouracil is a pyrimidine analog that exerts its cytotoxic effects by interfering with RNA and DNA synthesis in rapidly dividing cells. It is well-absorbed after injection and distributed to various tissues, including tumor sites.
Indications for Use:
- Treatment of colorectal cancer
- Management of breast cancer
- Therapy for skin cancer
Contraindications:
Fluorouracil solution is contraindicated in patients with a history of severe hypersensitivity reactions to fluorouracil or any components of the formulation. It should not be used in individuals with dihydropyrimidine dehydrogenase (DPD) deficiency.
Side Effects:
Common side effects of fluorouracil include myelosuppression, gastrointestinal disturbances, mucositis, dermatitis, and hand-foot syndrome. Severe adverse reactions may include cardiotoxicity, neurotoxicity, and infusion site reactions.
Usage Instructions:
Fluorouracil solution is administered intravenously or intra-arterially under the supervision of a healthcare professional. The dosage and administration schedule are individualized based on the patient’s condition and response to treatment.
Benefits Compared to Analogues:
Fluorouracil has demonstrated superior efficacy and safety profiles compared to some analogues in the treatment of specific cancer types. Its well-established mechanism of action and clinical effectiveness make it a preferred choice in oncology practice.
Suitable Patient Groups:
Fluorouracil can be used in adult patients across different age groups, including the elderly. Dosing adjustments may be necessary in patients with renal or hepatic impairment.
Storage Conditions and Shelf Life:
Store fluorouracil solution at controlled room temperature away from light and moisture. Check the product label for specific storage instructions. The shelf life of the product is typically mentioned on the packaging.
Packaging Description:
The product is supplied in a vial containing 20 ml of fluorouracil solution at a concentration of 50 mg/ml. Each vial is labeled with the necessary information regarding the drug name, strength, and volume.
Scientific Evidence:
Fluorouracil has been extensively studied in clinical trials, demonstrating its efficacy in various cancer types. Research has shown that fluorouracil plays a crucial role in improving survival outcomes and tumor response rates in cancer patients.
Additional Information:
Prior to initiating treatment with fluorouracil solution, patients should be informed about the potential side effects and monitored closely during therapy. Regular follow-up visits with healthcare providers are essential to evaluate treatment response and manage any adverse events effectively.
