Furosemid-Sofarma tablets 40 mg. №20

Description

Furosemid-Sofarma Composition
active substance: furosemide;

1 tablet contains furosemide 40 mg;

excipients: lactose monohydrate, wheat starch, colloidal anhydrous silicon dioxide, magnesium stearate, talc.

Furosemid-Sofarma Dosage form
Pills.

Basic physical and chemical properties: round biconvex tablets with a diameter of 6 mm, from white to almost white.

Furosemid-Sofarma Pharmacotherapeutic group
Diuretics Highly active loop diuretics. ATX code С03С А01.

Pharmacodynamics
Furosemide is a loop diuretic that inhibits the absorption of sodium and chlorine ions in the ascending part of Henle’s loop, proximal and distal tubules of the nephron. The high degree of effectiveness is due to the unique mechanism of action. The effect in the distal tubules is independent of the inhibitory effect of carbonic anhydrase or the effect of aldosterone. The pharmacological action of furosemide is limited only by the kidneys. The main mechanism of action of furosemide is to suppress active chloride transport in the ascending part of the loop. Resorption of sodium chloride in the nephron is reduced and hypo- or isotonic urine is formed.

It was found that the use of furosemide affects the synthesis of prostaglandins and the renin-angiotensin system. Furosemide also affects the permeability of the glomerulus in relation to serum proteins.

The onset of the diuretic effect begins approximately 1 hour after oral administration. The maximum therapeutic effect occurs between the first and second hours. The duration of the diuretic action is more than 4 hours.

Indications
Edema in chronic congestive heart failure (if treatment with diuretics is necessary);
edema in chronic renal failure;
edema with nephrotic syndrome (if treatment with diuretics is necessary);
acute renal failure, including in pregnant women or during childbirth;
edema in liver diseases (if necessary, to supplement treatment with aldosterone antagonists);
arterial hypertension.

Contraindications
Hypersensitivity to furosemide or to any of the excipients of the drug;
allergy to sulfonamides (for example, sulfonamide antibiotics or sulfonylureas) due to possible cross-sensitivity to furosemide;
hypovolemia or dehydration;
anuria or impaired renal function (creatinine clearance below 30 ml / min), renal failure with anuria, if there is no therapeutic response to furosemide;
renal failure due to poisoning with nephrotoxic or hepatotoxic drugs;
severe hypokalemia;
severe hyponatremia;
precomatose and coma associated with hepatic encephalopathy;
digitalis intoxication;
concomitant use of potassium preparations or potassium-sparing diuretics.