Glicin sublingual tablets 100 mg. №50

Description

Glicin sublingual Storage
active substance: Glycine;

1 sublingual tablet contains glycine 100 mg;

Excipients: povidone, montan glycol wax, ammonium methacrylate copolymer (type A), calcium stearate.

Glicin sublingual Dosage form
Sublingual tablets.

Main physical and chemical properties: white tablets with a bevel and a dash.

Glicin sublingual Pharmacotherapeutic group
Drugs acting on the nervous system.

ATX code N07X X.

Pharmacological properties

Pharmacodynamics.

Glycine is a substitute for amino acids. Glycine readily penetrates most body fluids and tissues, including the brain, and is metabolized; its accumulation in tissues does not occur. It is rapidly broken down in the liver by glycine oxidase to water and carbon dioxide.

Pharmacokinetics.

Glycine is a central neurotransmitter that regulates metabolism; normalizes and activates the processes of protective inhibition in the central nervous system. Improves metabolic processes in brain tissues, has antidepressant and sedative effects. Has glycine and GABA-ergic, alpha1-adrenoblocking, antioxidant, antitoxic effect; regulates the activity of glutamate (NMDA) receptors, thereby reducing psycho-emotional stress, aggression and conflict; increases social adaptation, improves mood; facilitates falling asleep and normalizes sleep, increases mental performance, reduces the severity of vascular disorders.

L-glycine (glycol) is involved in the synthesis of the most important substances for the body: nucleic acids, glutathione, bile acids and more. Glycine is used in the synthesis of porphyrin – the precursor of heme in the hemoglobin molecule, as well as purine bases – the most important elements of nucleic acids. Glycine is part of the structure of glutathione-containing substances, which plays a special role in the system of antiradial protection.

Glycine is involved in detoxification reactions, including in the composition of hippuric acid, as well as in the synthesis of bile acids (glycolic acid). In addition, glycine is important for the processes of oxalic acid biosynthesis.

Indication
Decreased mental capacity. In stressful situations and psycho-emotional stress (during exams, in conflict situations). Deviant behaviors of children and adults. Functional and organic diseases of the nervous system (neuroses, neurosis-like conditions, vegetative-vascular dystonia, consequences of neuroinfection and traumatic brain injury, perinatal and other forms of encephalopathy, including alcoholic genesis), which are accompanied by increased excitability, emotional instability sleep disorders.

Ischemic stroke and cerebrovascular disorders.

As an adjunct in the treatment of alcoholism.

Contraindication
Individual intolerance to the drug and hypersensitivity to its individual components; arterial hypotension. Children under 3 years.

Special security measures
Patients with a predisposition to hypotension should monitor blood pressure and, if necessary, adjust the dose of the drug: Glycine is prescribed in lower doses and subject to regular monitoring of blood pressure. At indicators of arterial pressure below usual level of drug use stop.