Indovazin gel 45 g.

Description

INDOVAZIN COMPOSITION
active ingredients: indomethacin, troxerutin

1 g of gel contains indomethacin 30 mg troxerutin 20 mg

Excipients:

INDOVAZIN DOSAGE FORM
Gel.

INDOVAZIN MAIN PHYSICAL AND CHEMICAL PROPERTIES:
slightly opalescent homogeneous gel, color – from yellow to yellow-brown.

PHARMACOLOGICAL GROUP
Angioprotectors. Capillary stabilizing agents. Troxerutin, combinations. ATX code С05С А54.

PHARMACOLOGICAL PROPERTIES
Pharmacological.

Indovazin is a combined drug that contains indomethacin and troxerutin.

Indomethacin has a pronounced anti-inflammatory, analgesic and decongestant effect. This results in pain relief, reduced swelling and shortened the recovery time for damaged joints and tissues. The mechanism of action is associated with the suppression of prostaglandin synthesis by reversible blockade of cyclooxygenase. Indomethacin has a pronounced anti-inflammatory effect in comparison with salicylates and phenylbutazone.

Troxerutin (Trihydroxyethylrutinoside) is a bioflavonoid. It belongs to Angioprotective agents. Troxerutin reduces capillary permeability and has a venotonic effect. Blocks the venodilating action of histamine, bradykinin and acetylcholine. It has an anti-inflammatory effect on perivenous tissues, reduces capillary fragility and has a certain antiplatelet effect. Reduces edema, improves trophism in pathological changes associated with venous insufficiency. When applied to the skin, Indovazin suppresses the reactions of inflammation and edema, eliminates pain and temperature in the foci of inflammation (outside and in deep tissues, reaching the blood vessels located there). It has a venotonic, capillaroprotective and hemostatic effect.

The ointment base of the preparation is selected in such a way that it ensures the complete solubility of the active substances and their maximum release. The dosage form in the form of a gel, which includes indomethacin and troxerutin, provides good absorption from the skin surface and a therapeutic effect at different levels, forming the necessary concentrations in nearby tissues and synovial fluid.

Pharmacokinetics.

Indomethacin binds to blood plasma proteins by more than 90% and undergoes intensive biotransformation in the liver by O-demethylation and N-deacetylation to inactive compounds. Troxerutin is a mixture of hydroxyethyl derivatives of bioflavonoids rutin, in which trihydroxyethylrutoside (troxerutin) predominates.

Indomethacin is excreted in urine (60%), bile and feces (30%). Penetrates into breast milk, therefore it is not recommended to use the drug during lactation.

Most of the resorbed tri-, di- and monohydroxyethylrutosidive is excreted in the bile, a much smaller part is excreted by the kidneys. Tetrahydroxyethylrutoside is excreted mainly in the urine.

INDICATIONS
Indovazin gel is intended for the symptomatic treatment of:

manifestations of venous insufficiency (edema, feeling of heaviness and pain in the legs)
varicose veins
superficial thrombophlebitis, phlebitis
conditions after phlebitis
in the complex therapy of hemorrhoids
soft tissue rheumatism tendovaginitis, bursitis, fibrositis, periarthritis
edema after surgery
bruises, dislocations, sprains.

CONTRAINDICATIONS
Hypersensitivity (allergy) to the active substance and / or to any of the components of the drug.

Hypersensitivity to NSAIDs (NSAIDs).

Bronchial asthma.

The gel should not be applied to mucous membranes, open wound surfaces or in the eyes.