Loraxim (cefotaxime) powder 1000 mg. №1 vial

Description

Loraxim composition
active substance: cefotaxime;
Each vial contains cefotaxime sodium in an amount corresponding to cefotaxime 1000 mg.

Dosage form
Powder for solution for injection.

Pharmacological properties
Loraxim is a semi-synthetic antibacterial drug for systemic use with a wide spectrum of action. The active ingredient is cefotaxime, which is a third-generation cephalosporin. It is used parenterally (bypassing the gastrointestinal tract).
It is active in relatively sensitive microorganisms due to its property to disrupt the work of cell membranes.

Indications
Loraxim is used to treat infections that are susceptible to cefotaxime. In particular, this drug effectively treats infections that cause diseases:

• lower and upper respiratory tract, including ENT organs (tonsillitis, otitis media, bronchitis, pneumonia, pleurisy, abscesses);
• genitourinary system;
• skin, soft tissues (abscesses, phlegmon, gangrene of the extremities);
• bones and joints (bacterial arthritis, osteomyelitis);
• small pelvis;
• abdominal cavity (peritonitis, cholecystitis, cholangitis);
• meningitis (other than listeria) and other infections of the central nervous system.

It can be used to prevent the development of postoperative complications during abdominal, urological, obstetric and gynecological operations.

Contraindications
Do not use for allergies to drugs of the cephalosporin group, as well as to other β-lactam antibiotics.
Contraindicated in case of hypersensitivity to lidocaine (with intramuscular injection), bleeding, history of enterocolitis.
It is not prescribed for AV-blockade without an established heart rate driver, severe heart failure.

Children
Children under 2.5 years of age should not be given intramuscularly.

Application during pregnancy and lactation
The use of this drug for the treatment of pregnant women is contraindicated.
During breastfeeding, the drug passes into breast milk. As a result, during the treatment process, lactation should be suspended.

Method of administration and dosage
Loraxim is used as an intravenous injection (in the form of a dropper and a jet), as well as intramuscularly. Before use, a test is carried out for sensitivity to an antibiotic and to lidocaine (in the case of intramuscular administration, in which lidocaine is used as a solution).

• For adults and children weighing more than 50 kg, this drug is prescribed in a dosage of 1 gram (1000 mg) every 12 hours. In severe cases, it is permissible to increase the frequency of administration to 3-4 per day (at the same dosage). The maximum daily dose is 12 grams.
• Children weighing up to 50 kg are prescribed a daily dosage of 50 to 100 mg per 1 kg of body weight. The drug is administered with a frequency of 3-4 times a day. In severe cases, the dosage can be increased to 100-200 mg per 1 kg of body weight, increasing the frequency of administration up to 4-6 times a day.

In uncomplicated gonorrhea, this drug is prescribed in a dosage of 1 gram intramuscularly, once.
Moderate infections are treated with 1–2 grams of Loraxim every 12 hours. In severe infections, for example, with meningitis, the dosage can be increased to 2 grams of the drug (intravenously) with a frequency of administration every 6-8 hours.
As a prophylactic agent for surgery, cefotaxime is administered once, in a dosage of 1 gram. If necessary, the introduction is repeated after 6-12 hours.
With renal failure, the dosage is halved.
The preparation of the solution for injection is carried out by qualified medical personnel in accordance with the requirements specified in the special medical literature.

Overdose
In case of an overdose, the occurrence of:

• fever, leukopenia, thrombocytopenia, encephalopathy, acute hemolytic anemia;
• skin and gastrointestinal reactions, as well as reactions from the liver;
• shortness of breath, renal failure, stomatitis;
• anorexia, temporary hearing loss and spatial orientation.

The use of hemodialysis is recommended, the treatment of symptoms.
No specific antidote has been identified.

Side effects
Side effects are usually mild and do not interfere with continuing treatment. Most often they appear as:

• nausea, vomiting, pseudomembranous colitis, flatulence, diarrhea (diarrhea), glossitis, dysbiosis;
• skin rash, urticaria, exanthema, hyperemia, bronchospasm, anaphylactic reactions, angioedema;
• jaundice, hepatitis, liver dysfunction;
• neutropenia, eosinophilia, thrombocytopenia, agranulocytosis, eosinophilia, hypoprothrombinemia;
• pain and infiltrates at the site of intramuscular injection, phlebitis along the vein.

Storage conditions and periods
Shelf life – up to 3 years at a temperature not exceeding 30 ° C.