Description

Lospirin (acetylsalicylic acid) tablets 75 mg. №30

Ingredients

Active ingredient: Each tablet contains 75 mg of acetylsalicylic acid.

Dosage

Dosage: Take **one tablet** by mouth once daily with a full glass of water, or as directed by your healthcare provider.

Indications

Indications: Lospirin tablets are indicated for the relief of minor aches and pains and for the reduction of fever.

Contraindications

Contraindications: Do not take Lospirin if you are allergic to acetylsalicylic acid or any other ingredients in the product. Avoid use in children under 12 years old unless directed by a doctor.

Directions

Directions: Swallow the tablet whole with water. Do not crush or chew the tablet. **Do not exceed the recommended dosage.**

Scientific Evidence

Acetylsalicylic acid, the active ingredient in Lospirin, is a well-studied medication with a long history of use. Research has shown that acetylsalicylic acid works by inhibiting the production of prostaglandins, which are substances in the body that cause pain and inflammation. This mechanism of action makes it effective in relieving pain and reducing fever.

Additional Information

It is important to note that while acetylsalicylic acid is widely used, it is not without risks. **Long-term use of high doses** can lead to gastrointestinal complications and an increased risk of bleeding. It is essential to follow the recommended dosage and consult a healthcare professional if you have any concerns.

Pharmacological Effects

Acetylsalicylic acid, a nonsteroidal anti-inflammatory drug (NSAID), exerts its pharmacological effects by irreversibly inhibiting the enzyme cyclooxygenase (COX), thereby reducing the production of prostaglandins involved in inflammation, pain, and fever. Additionally, acetylsalicylic acid has antiplatelet effects, making it valuable in the prevention of cardiovascular events.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of acetylsalicylic acid in various conditions, including cardiovascular diseases, pain management, and fever reduction. Compared to other NSAIDs, acetylsalicylic acid stands out for its unique antiplatelet properties, making it a cornerstone in the prevention of heart attacks and strokes.

References:
1. Patrono C, García Rodríguez LA, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353(22):2373-2383.
2. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817.