Lucetam 400 (piracetam) coated tablets 400 mg. №60 vial

Description

Lucetam 400 composition
active substance: piracetam;
1 tablet contains 400 mg of piracetam;
excipients: magnesium stearate, povidone, dibutyl sebacate;
tablet composition: Opadry 03F28561 white (macrogol, titanium dioxide (E 171), talc, ethylcellulose aqueous dispersion, hypromellose).

Dosage form
Film-coated tablets.

Pharmacological properties
The active ingredient in Lucetam 400 is piracetam, a cyclic derivative of gamma-aminobutyric acid. Piracetam is a nootropic drug that acts on the brain, improving cognitive functions such as learning ability, memory, attention, and mental performance in healthy people and patients with cognitive impairments. These effects are not related to sedation or stimulants. The effects of piracetam are associated with the stimulation of nucleotide metabolism in neurons, increased glucose levels and oxygen utilization in the brain, as well as enhanced cholinergic and dopaminergic mechanisms of excitation transmission in nervous tissue. Piracetam has the property of dose-dependent binding to the phospholipid double layer of cell membranes, and it restores their structure, thus increasing fluidity and improving membrane function.

Indications
Lucetam 400 is used in therapy:

• consequences of ischemic strokes, which are accompanied by speech impairment, as well as motor and mental activity;
• psychoorganic syndromes, accompanied by dizziness, decreased memory, behavioral disorders, emotional lability, decreased concentration of attention, unsteady gait;
• senile dementia of the Alzheimer’s type and Alzheimer’s disease;
• dizziness and disturbances in balance, with the exception of dizziness of mental origin;
• chronic alcoholism and disease-induced withdrawal and psychoorganic syndromes;
• cortical myoclonus;
• low learning ability in children, especially when receiving specific skills in counting, reading, writing, which cannot be explained by inadequate teaching, mental retardation or family environment.

In addition, the appointment of Lucetam is indicated in the recovery period after injuries and intoxication of the brain.

Contraindications
Lucetam is not prescribed for patients who have had a hemorrhagic stroke, with renal failure, hypersensitivity to the active and auxiliary substances of the drug or pyrrolidone derivatives. It is unacceptable to use the drug in the treatment of nursing and pregnant women.

Application during pregnancy and lactation
Due to the fact that there have been no controlled studies regarding the safety of using this drug in the treatment of pregnant women, its appointment to this category of patients is unacceptable.
Piracetam is able to penetrate the placental barrier and be excreted in breast milk, therefore, when prescribing Lucetam to nursing patients, patients are recommended to refuse lactation.

Method of application and dosage
Apply the drug orally, drinking a small amount of water.

• Treatment of conditions accompanied by memory impairment, cognitive disorders.
  The initial daily dose is 4.8 g during the first week of treatment. Usually the dose should be divided into 2-3 doses.
  The maintenance dose is 2.4 g per day, which is divided into 2-3 doses.
  In the future, it is possible to gradually reduce the dose by 1.2 g per day.
• Treatment of cortical myoclonus
  The initial daily dose is 24 g for 3 days. If during this time the desired therapeutic effect is not achieved, continue to use the drug in the same dosage (24 g / day) for up to 7 days. If on the 7th day of treatment the desired therapeutic effect is not obtained, treatment should be stopped. If the therapeutic effect has been achieved, then from the day when a steady improvement is achieved, begin to reduce the dose of the drug by 1.2 g every 2 days until the manifestations of cortical myoclonus reappear. This will allow you to set the average effective dose.
  Divide the daily dose into 2-3 doses. Treatment with other antimyoclonic agents is maintained in pre-prescribed doses. Continue treatment until the symptoms disappear. To prevent deterioration of patients can not abruptly stop using the drug. It is necessary to gradually reduce the dose by 1.2 g every 2-3 days. It is necessary to prescribe repeated courses of drug treatment every 6 months, adjusting the dose depending on the patient’s condition, until the disappearance or reduction of the disease.

Overdose
Due to the fact that the active substance Lucetam piracetam does not have a toxic effect even in high doses, only isolated cases of drug overdose have been officially registered. When taking high doses of Lucetam for a long time, patients develop dyspeptic disorders, abdominal pain and diarrhea.
To improve the patient’s condition, he undergoes induction of vomiting, gastric lavage and the necessary symptomatic treatment is prescribed.

Side effects
When taking Lucetam, some patients experience irritability, depression, headaches, drowsiness, insomnia, anxiety, dizziness, imbalance, exacerbation of epilepsy, hallucinations, increased libido, confusion, changes in blood pressure, dyspeptic disorders, epigastric pain, weight gain, etc. allergic reactions.

Storage conditions and periods
The drug should be stored in a dry and dark place, out of reach of small children. The shelf life is 5 years.