Description

Maninil (glibenclamide) tablets 5 mg. №120 vial

Ingredients

Active ingredient: Glibenclamide 5 mg per tablet.

Dosage

Recommended dosage: The usual starting dose is 2.5 to 5 mg daily, taken with breakfast. Dosage adjustments should be made based on blood glucose levels.

Indications

Maninil tablets are indicated for the treatment of type 2 diabetes mellitus when diet alone has failed to control blood sugar levels adequately.

Contraindications

Do not use Maninil tablets in patients with type 1 diabetes, diabetic ketoacidosis, severe liver or kidney dysfunction, or a history of hypersensitivity to sulfonylureas.

Directions

Take Maninil tablets exactly as prescribed by your healthcare provider. Swallow the tablets whole with a glass of water. It is usually taken once daily with breakfast.

Scientific Evidence

Glibenclamide, the active ingredient in Maninil tablets, works by stimulating the release of insulin from the pancreas, thereby lowering blood sugar levels. Studies have shown that glibenclamide is effective in improving glycemic control in patients with type 2 diabetes.

Additional Information

It is important to monitor blood glucose levels regularly while taking Maninil tablets to ensure optimal control of diabetes. Inform your healthcare provider about all medications you are taking to avoid potential drug interactions.

Pharmacological Effects: Glibenclamide belongs to the sulfonylurea class of drugs, which act by increasing insulin release from pancreatic beta cells. This leads to a decrease in blood glucose levels, helping to manage diabetes.

Clinical Trials: Clinical trials have demonstrated the efficacy of glibenclamide in improving HbA1c levels and overall glycemic control in patients with type 2 diabetes. In a study by Kahn et al., glibenclamide was shown to significantly reduce fasting plasma glucose levels compared to placebo.