Description

Meditan (gabapentin) capsules 400 mg. №30

Ingredients

Each capsule contains 400 mg of gabapentin.

Dosage

The usual dose is 300-600 mg three times a day. Dosage may vary based on the condition being treated. Consult a healthcare professional for personalized recommendations.

Indications

Meditan capsules are indicated for the management of seizures and neuropathic pain. It is also used to treat restless legs syndrome and certain types of nerve pain.

Contraindications

Do not use Meditan if you are allergic to gabapentin or any of the ingredients in the product. It is important to inform your doctor about any medical conditions or medications you are taking before starting gabapentin.

Directions

Take Meditan capsules orally with or without food as directed by your physician. Swallow the capsules whole with a full glass of water. Do not crush or chew the capsules.

Scientific Evidence

Gabapentin, the active ingredient in Meditan, works by stabilizing electrical activity in the brain and affecting the way nerves send messages to the brain. Studies have shown its efficacy in reducing seizures and managing neuropathic pain. Research published in the *Journal of Pain Research* demonstrated the effectiveness of gabapentin in treating diabetic neuropathy.

Additional Information

It is important to follow the prescribed dosage and not exceed the recommended amount. Abruptly stopping gabapentin can lead to withdrawal symptoms. Inform your healthcare provider about any side effects experienced while taking Meditan capsules.

Pharmacological Effects

Gabapentin exerts its pharmacological effects by binding to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This action inhibits the release of excitatory neurotransmitters, thereby reducing neuronal hyperexcitability. By modulating calcium influx, gabapentin helps in controlling seizures and neuropathic pain.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of gabapentin in various neuropathic pain conditions, including postherpetic neuralgia and fibromyalgia. In comparative studies, gabapentin has shown similar or better effectiveness compared to other antiepileptic drugs in managing seizures and neuropathic pain. Research published in the *European Journal of Pain* highlighted the favorable tolerability profile of gabapentin in long-term use.

• Gabapentin stabilizes electrical activity in the brain.
• It is effective in reducing seizures and managing neuropathic pain.
• Research supports the use of gabapentin in diabetic neuropathy.
• Follow the prescribed dosage to avoid withdrawal symptoms.