Description

Metformin Kanon (metformin) Coated Tablets 1000 mg. №30

Ingredients

Active ingredient: Metformin hydrochloride 1000 mg.
Other ingredients: Microcrystalline cellulose, povidone K30, croscarmellose sodium, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide (E171).

Dosage

Recommended dosage: The usual starting dose is 500 mg or 850 mg once daily with meals. The maximum recommended dose is 2000 mg per day in divided doses.

Indications

Metformin Kanon tablets are indicated for the treatment of type 2 diabetes mellitus in adults, particularly in overweight patients when dietary management and exercise alone have not been sufficient to control blood glucose levels.

Contraindications

Do not use Metformin Kanon tablets if you have severe kidney disease, metabolic acidosis, or a history of lactic acidosis. It is contraindicated in patients with hypersensitivity to metformin or any component of the formulation.

Directions

Take Metformin Kanon tablets exactly as prescribed by your healthcare provider. Swallow the tablets whole with a full glass of water during meals to reduce the risk of gastrointestinal side effects.

Scientific Evidence

Metformin, the active ingredient in Metformin Kanon tablets, works by decreasing glucose production in the liver and improving insulin sensitivity in the body’s tissues. Several studies have demonstrated the efficacy of metformin in lowering blood glucose levels and reducing hemoglobin A1c in patients with type 2 diabetes.

Additional Information

Metformin has been shown to have additional benefits beyond glycemic control, including potential cardiovascular protection and weight loss in some patients. It is considered a first-line therapy for type 2 diabetes due to its safety profile and proven efficacy in numerous clinical trials.

Pharmacological Effects: Metformin primarily works by decreasing hepatic glucose production and increasing insulin sensitivity in peripheral tissues. This dual mechanism helps to lower blood glucose levels and improve overall glycemic control in patients with type 2 diabetes.

Clinical Trials: Clinical trials have shown that metformin not only effectively lowers blood glucose levels but also reduces the risk of diabetes-related complications such as cardiovascular events and kidney disease. One study published in the New England Journal of Medicine found that metformin reduced the risk of cardiovascular events in diabetic patients compared to other antidiabetic medications.