Metipred (methylprednisolone) tablets 4 mg. №30 vial

$24.00

Prescribe the drug in case of insufficient production of hormones by the adrenal glands, genetic proliferation of adrenal tissue (hyperplasia), inflammation of the thyroid gland, various forms of autoimmune diseases (anemia, leukemia).

Category:

Description

Metipred composition
active substance: methylprednisolone;
1 tablet contains methylprednisolone 4 mg;
excipients: lactose monohydrate, corn starch, gelatin, magnesium stearate, talc.

Dosage form
Tablets.

Pharmacological properties
A hormonal preparation containing methylprednisolone. Responsible for the synthesis of enzymes and proteins, prevents the destruction of joints and cytokines, which are involved in immune and inflammatory processes.
It is most effective in anti-inflammatory processes – its effect is 5 times more powerful than hydrocortisone.
Metipred regulates and influences metabolic processes in the body – lipid, protein, carbohydrate and calcium.
With prolonged use, it can cause atrophy of the muscles and adrenal cortex.
The drug is well absorbed in the digestive tract of the body. Begins to act 8 hours after ingestion.

Indications
The drug Metipred is prescribed for insufficient production of hormones by the adrenal glands, genetic proliferation of adrenal tissue (hyperplasia), inflammation of the thyroid gland, and various forms of autoimmune diseases (anemia, leukemia).
The drug is taken in severe, specific forms of erythremia, psoriasis, dermatitis.
Copes well with severe forms of allergies, anaphylactic shock.
It is prescribed for the treatment of severe acute, chronic inflammatory processes in the tissues of the body – with tuberculosis in combination with chemotherapy.
With severe forms of rheumatism, arthritis, lower respiratory tract diseases, asthma.
It is prescribed for postoperative cerebral edema or due to tumors. And also in other conditions that are characterized by increased intracranial pressure.
With ulcerative colitis, Crohn’s disease, multiple sclerosis.
Metipred can be used in the postoperative period during organ transplantation to prevent transplant rejection, in patients undergoing chemotherapy as an antiemetic.

Contraindications
In case of an allergic reaction to methylprednisalone, lactose.
Not indicated for acute or chronic viral or bacterial infectious diseases.
With a latent or active form of tuberculosis, if other treatment is not carried out in parallel.
Arterial hypertension, congestive heart failure, mental disorders, diabetes mellitus, pancreatitis, old age – these are all reasons for careful use of the drug or an obstacle to not prescribing it.
Diseases of the stomach or intestines where there is a risk of bleeding opening or perforation.
Carefully weigh the risks when prescribing the drug to individuals with glaucoma, thrombophlebitis, diabetes mellitus in the family, fragility of bones and poor blood clotting.
For patients suffering from functional disorders of the liver and with hypothyroidism, the drug can be prescribed only under scrupulous medical supervision.

Children
The drug is used in pediatric practice.

Application during pregnancy and lactation
When using metipred by a pregnant woman, the high risks of a stillborn child and fetal growth arrest should be taken into account.
If a woman was taking the drug, became pregnant, the dose should be gradually reduced and the medication should be “nil”. You cannot abruptly stop taking the drug.
When breastfeeding a child, taking the drug is contraindicated; in extreme cases, breastfeeding should be canceled.

Method of administration and dosage
The starting dose for adults can range from 4 mg to 48 mg methylprednisolone per day, depending on the nature of the disease. For less severe medical conditions, lower doses are usually sufficient, although higher starting doses may be required for selected patients. High doses can be used for diseases and conditions such as multiple sclerosis (200 mg / day), cerebral edema (200-1000 mg / day) and organ transplantation (up to 7 mg / kg / day).
If, as a result of therapy, a satisfactory effect is achieved, the patient should select an individual maintenance dose by gradually decreasing the initial dose at regular intervals until the lowest dose is found that will maintain the achieved clinical effect. It should be remembered that constant monitoring of the dosage regimen of the drug is necessary. There may be situations in which you need to adjust the dose; these include changes in the clinical state due to the onset of remission or exacerbation of the disease, the patient’s individual response to the drug, as well as the effect on the patient of stressful situations that are not directly related to the underlying disease to which the therapy is directed; in the latter case, it may be necessary to increase the dose of the drug for a certain period of time, which depends on the patient’s condition. The required dose may vary and should be selected individually, depending on the nature of the disease and the patient’s response to therapy.
The dosage of the drug should be individualized and based on an assessment of the course of the disease and clinical effect.
Cancellation of the drug should not be carried out suddenly – it should be done gradually.

Alternating therapy
Alternative therapy is a corticosteroid dosing regimen in which twice the daily dose of a corticosteroid is given every other day, in the morning. The goal of this type of therapy is to achieve the maximum clinical effect in a patient requiring long-term therapy while minimizing some undesirable effects, such as suppression of the pituitary-adrenal system, Cushing’s syndrome, corticosteroid withdrawal syndrome and growth retardation in children.

Overdose
Overdose data have been reported. With prolonged use of the drug, it is possible to suppress the function of the adrenal glands.
When such a symptom appears, the dose of the drug is gradually reduced.

Side effects
Long-term treatment with the drug in childhood can lead to growth retardation.
Possible withdrawal syndrome – to avoid this, you should gradually reduce the dose of the drug.
The drug sometimes negatively affects cardiovascular (increased blood pressure, heart failure, leukocytosis), gastrointestinal (bulimia, mucosal lesions, ulcers, nausea), nervous (sleep disturbances, the appearance of gaucoma, exacerbation of schizophrenia, increased intraocular pressure), musculoskeletal motor (osteoporosis, myopathy, tendon dysfunctions) systems.
Possible water retention in the body, menstrual irregularities, weight gain, amenorrhea, rash, itching, allergic reactions.
With injections, a burning sensation and pain at the injection site are possible.
Abrupt withdrawal of the drug can cause high fever, pain in muscles and joints.

Shelf life
5 years.

Storage conditions
Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.