Description

Metrogyl (Metronidazole) Solution for Infusions 5 mg/ml. 100 ml

Ingredients

Active ingredient: Metronidazole. Inactive ingredients may include sodium chloride, citric acid, and water for injections.

Dosage

Dosage: The usual dose is 500 mg infused over 1 hour every 8 hours. Dosage may vary based on the condition being treated.

Indications

Indications: Metrogyl is indicated for the treatment of infections caused by susceptible anaerobic bacteria and parasites.

Contraindications

Contraindications: Do not use in patients with a history of hypersensitivity to metronidazole or other nitroimidazole derivatives.

Directions

Administration: Administer by slow intravenous infusion over 1 hour. Do not mix with other drugs or infusions.

Scientific Evidence

Metronidazole, the active ingredient in Metrogyl, exerts its antimicrobial effects by disrupting the DNA of microbial cells, leading to cell death. Studies have shown its efficacy in treating various infections, including intra-abdominal infections and bacterial vaginosis. Research by Petrin et al. (2002) demonstrated the effectiveness of metronidazole in eradicating Helicobacter pylori, a common cause of gastric ulcers.

Additional Information

Metrogyl should be used with caution in patients with a history of blood disorders or neurological conditions. It is important to complete the full course of treatment as prescribed by a healthcare provider to ensure the infection is fully eradicated.

Pharmacological Effects: Metronidazole works by entering bacterial and protozoal cells and causing damage to their DNA, leading to cell death. It is particularly effective against anaerobic bacteria and certain parasites.

Clinical Trials: Clinical trials have shown Metrogyl to be comparable in efficacy to other antibiotics in the treatment of various infections. A study by Brown et al. (2015) compared the effectiveness of metronidazole with clindamycin in the treatment of intra-abdominal infections, with similar success rates observed in both groups.