Mirtazapin Sandoz coated tablets 30 mg. №20

Description

Mirtazapin Sandoz composition
Main active ingredient: mirtazapine (30 mg).
Excipients: lactose monohydrate, corn starch, hydroxypropyl cellulose, colloidal anhydrous silicon dioxide, magnesium stearate, etc. (dyes).

Release form
The drug is produced in tablet form.

Pharmacological properties
Mirtazapin Sandoz belongs to the group of antidepressants based on the active ingredient mirtazapine.
Mirtazapine – an alpha-receptor antagonist, has the property of enhancing the transmission of certain groups of nerve impulses, in particular, central noradrenergic and central serotonergic impulses.
This effect of enhancing the transmission of serotonergic impulses when using this drug is possible only through the use of 5-HT1 receptors, since mirtazapine has the property of blocking 5-HT2 and 5-HTZ receptors.
In addition to antidepressant activity, mirtazapine also has a sedative effect, since it is also capable of blocking H1 receptors.
If the patient does not exceed the recommended dosages during treatment, the use of mirtazapine does not produce an anticholinergic effect, and also does not affect the heart muscle and the circulatory system.
The drug has the property of being perfectly absorbed into the blood, therefore, the maximum concentration in the blood is observed two hours after its oral administration.

Indications
Mirtazapin Sandoz is indicated for the treatment of conditions of major depression, major depressive episode.

Contraindications
The drug in question is not used if the patient has ever had hypersensitivity (allergy) to one of the components that make up its composition.
It is contraindicated to use concomitantly with monoamine oxidase inhibitors (MAO).
Caution should be exercised when using in patients with moderate and / or severe renal insufficiency.
When treating, take into account that the drug can enhance the effect of other sedatives.

Children
It is not used to treat children, because this drug may cause suicidal ideation in children.

Application during pregnancy and lactation
Treat pregnant women with all possible caution, taking into account the potential risk to the fetus.
Breastfeeding should be suspended during treatment.

Method of administration and dosage
Usually a tablet of Mirtazapin Sandoz is taken once a day, before going to bed. The drug is swallowed without breaking, drinking a sufficient amount of liquid.
In some cases, the reception is divided into 2 doses at regular intervals throughout the day – in the morning and in the evening, while the dosage is reduced.
The average recommended dosage is 15 to 45 mg per day. The effect usually occurs after 1-2 weeks of regular administration of the drug. If the effectiveness is insufficient, the doctor may increase the dosage. If after 4 weeks no positive dynamics is observed, then the drug should be canceled.
The duration of the course of treatment depends on when the symptoms of the disease disappear. This usually occurs within 6 months of regularly taking the drug.
Cancellation of the drug is made gradually, reducing the dosage to avoid “withdrawal syndrome”.
In renal failure, the level of creatinine clearance should be monitored.
If the patient has liver failure, the dosage should be reduced and the patient’s condition should be monitored further during further therapy.

Overdose
An overdose of this drug can manifest itself in the form of symptoms such as:

• oppression of the central nervous system;
• disorientation, prolonged sedation;
• tachycardia, changes in blood pressure (both decrease and increase).

With a massive overdose, a fatal outcome is possible.
It is recommended to perform symptomatic therapy – to wash out the stomach, take enterosorbents.

Side effects
Patients may experience the following side effects with this drug:

• bone marrow suppression, granulocytopenia, agranulocytosis, aplastic anemia, thrombocytopenia, eosinophilia;
• increased appetite, overeating, weight gain;
• hyponatremia;
• confusion, anxiety, insomnia, nightmares, mania, agitation, hallucinations, psychomotor agitation, drowsiness, tremors, lethargy;
• suicidal thoughts, behavior;
• convulsions;
• arterial hypotension;
• dry mouth, nausea, diarrhea, vomiting, swelling of the oral mucosa;
• exanthema, bullous dermatitis, erythema multiforme, oxic epidermal necrolysis;
• arthralgia, back pain;
• swelling, fatigue.

Storage conditions and periods
This medicinal product retains its medicinal properties for 3 years, which are counted from the production date specified by the manufacturer.
The drug should be kept out of the reach of children. Storage temperature should not exceed 25 ° C.