Description

Nalbufin (nalbuphine hydrochloride) ampoules 10 mg/ml. 2 ml. №5

Ingredients:

Each ampoule contains 10 mg of nalbuphine hydrochloride.

Dosage:

The recommended dosage is determined by a healthcare provider based on individual needs. Nalbufin is typically administered via intramuscular or intravenous injection.

Indications:

Nalbufin is indicated for the relief of moderate to severe pain. It is commonly used in postoperative settings, labor and delivery, and chronic pain management.

Contraindications:

Do not use Nalbufin in patients with a known hypersensitivity to nalbuphine hydrochloride or in those with respiratory depression. Caution is advised in patients with a history of substance abuse.

Directions:

Administer Nalbufin as directed by a healthcare professional. The injection should be given slowly to minimize the risk of adverse effects.

Scientific Evidence:

Nalbufin, a mixed opioid agonist-antagonist, provides effective pain relief with a lower risk of respiratory depression compared to pure opioid agonists. Studies have shown its efficacy in various pain conditions, making it a valuable option in pain management protocols.

Additional Information:

Nalbufin’s unique pharmacological profile allows for effective pain control while reducing the potential for abuse and dependence seen with traditional opioids. Clinical trials have demonstrated its efficacy in providing analgesia comparable to morphine but with a more favorable side effect profile.

Pharmacological Effects: Nalbufin acts as a kappa-opioid receptor agonist and a mu-opioid receptor antagonist, producing analgesia through multiple mechanisms. Its dual action results in a ceiling effect on respiratory depression, making it a safer option in patients at risk for opioid-related complications.

Comparative Effectiveness: In comparative studies, Nalbufin has shown similar analgesic efficacy to morphine in acute pain settings while causing less sedation and respiratory depression. Its unique pharmacodynamic profile makes it a valuable alternative in pain management, especially in patients with respiratory compromise.