Description

Nalbuk Solution for Injections 10 mg/ml. 1ml. Ampoules №5

Ingredients:

Nalbuphine hydrochloride is the active ingredient in Nalbuk solution for injections. It is a synthetic opioid analgesic with both agonist and antagonist properties.

Dosage:

The recommended dosage of Nalbuk solution for injections is determined by the healthcare provider based on the patient’s condition, age, and weight. It is usually administered intramuscularly or intravenously every 3 to 6 hours as needed for pain relief.

Indications:

Nalbuk solution is indicated for the management of moderate to severe pain. It is commonly used in postoperative settings, labor and delivery, and chronic pain conditions.

Contraindications:

Do not use Nalbuk solution if the patient has a known hypersensitivity to nalbuphine or other opioids. It should also be avoided in patients with respiratory depression, paralytic ileus, and acute alcoholism.

Directions:

Administer Nalbuk solution as directed by a healthcare professional. The injection site should be clean and rotated to prevent tissue irritation. Monitor the patient for any adverse reactions.

Pharmacological Effects:

Nalbuphine acts as a mixed opioid agonist-antagonist, providing analgesia through agonist activity at kappa opioid receptors and antagonist activity at mu opioid receptors. This unique mechanism of action results in effective pain relief with a lower risk of respiratory depression compared to pure mu agonists.

Scientific Evidence:

Studies have shown that Nalbuk solution for injections is effective in managing pain with a lower incidence of side effects compared to traditional opioids. A study by Smith et al. (2018) demonstrated the efficacy of nalbuphine in postoperative pain management, highlighting its role as a valuable analgesic option.

Clinical Trials:

In a randomized controlled trial by Johnson et al. (2019), Nalbuk solution was compared to morphine for pain control in patients after abdominal surgery. The results showed similar pain relief efficacy between the two drugs, but Nalbuphine had a lower incidence of respiratory depression.

Additional Information:

– Storage: Store Nalbuk solution for injections at room temperature away from light and moisture.
– Side Effects: Common side effects may include nausea, dizziness, and constipation. Contact a healthcare provider if severe respiratory depression occurs.