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Nitroxolin is used: with acute and chronic infections of the genitourinary system (pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or carcinoma of the prostate gland); for the prevention of infection during instrumental manipulations (catheterization of the bladder, cystoscopy); for the treatment of urinary tract infections of various origins during pregnancy (in the first and second trimesters).
Description
Nitroxolin composition and form of release
Active ingredient: nitroxoline (50 mg).
Available in tablet form.
Pharmacological properties
It is a chemotherapeutic agent (synthetic uro-antiseptic) with a wide range of action. The spectrum of its antifungal and antibacterial activity extends to most pathogens that infect the urinary tract. Derived from 8-hydroxyquinoline. Acts by the chelation mechanism. Selectively (selectively) inhibits the synthesis of bacterial DNA, forming complexes with metal-containing enzymes of the microbial cell, preventing their binding to specific substrates. This determines its bacteriostatic, bactericidal and fungicidal action. The drug is active against gram-positive, gram-negative microorganisms, including S. haemolyticus, S. aureus, S. faecalis, N. gonorrhoeae, Diplococcus pneumoniae, Corynebacterium diphtheriae, E. coli, M. tuberculosis, Proteus spp., Salmonella spp., Klebsiella spp., Shigella spp., Pneumobacillus spp., Enterobacter spp., B. subtilis, Candida spp., T. vaginalis, molds, dermatophytes, some pathogens of systemic mycoses.
Indications
Nitroxolin is used:
- with acute and chronic infections of the genitourinary system (pyelonephritis, cystitis, urethritis, epididymitis, infected adenoma or carcinoma of the prostate gland);
- for the prevention of infection during instrumental manipulations (catheterization of the bladder, cystoscopy);
- for the treatment of urinary tract infections of various origins during pregnancy (in the first and second trimesters).
Contraindications:
- with an allergy to an active ingredient;
- with intolerance to auxiliary components;
- with severe liver damage;
- with neuritis;
- with polyneuritis.
Application during pregnancy and lactation
It is suspected that aminosalicylates during pregnancy can cause birth defects in the fetus. Not recommended for use in the third trimester. The drug is excreted in breast milk, therefore breastfeeding is stopped during the treatment period.
Method of administration and dosage
Nitroxolin is administered orally.
The standard dose for adults is 600-800 mg per day, divided into 3-4 doses with an interval of 6-8 hours, the course is 10-14 days, the maximum is 1000-1200 mg / day.
The standard dose for children is 10-30 mg / kg / day in 3-4 divided doses.
For chronic recurrent infections, the course of treatment is usually several months.
Overdose
Symptoms: vomiting, nausea, general weakness.
Treatment: in the first four hours, gastric lavage, enterosorbents are recommended, symptomatic therapy is prescribed.
Side effects:
- Digestive disorders: nausea, loss of appetite, vomiting.
- Hepatobiliary disorders: impaired liver function, decreased activity of hepatic transaminases.
- Cardiovascular disorders: tachycardia.
- Neurological / mental disorders: dizziness, impaired coordination of movements, headache, paresthesias, general weakness, polyneuropathy.
- Allergic reactions: itching, skin rash, allergic reactions with the development of thrombocytopenia.
- Urinary disorders: a decrease in the content of uric acid in the blood.
- Other: general weakness.
Since nitroxoline is excreted by the kidneys, urine may turn intense yellow during treatment.
Storage conditions and periods
Store Nitroxolin at temperatures up to + 25 ° C for no more than two years.
Store the drug in its original packaging.
It is forbidden to use the medicine after the expiration date.
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