Description

No-shpa Solution for Injections Ampoules 20 mg/ml. 2 ml. №5

Ingredients:

Each 2 ml ampoule contains 20 mg of Drotaverine Hydrochloride.

Dosage:

The usual dose is 40-80 mg per day, divided into 2-3 administrations. Dosage may vary based on individual patient needs and medical condition.

Indications:

No-shpa Solution for Injections is indicated for the treatment of smooth muscle spasms. It is commonly used to relieve pain and discomfort associated with conditions such as renal colic, biliary colic, and dysmenorrhea.

Contraindications:

Do not use No-shpa Solution for Injections in cases of hypersensitivity to Drotaverine or other ingredients in the formulation. It is also contraindicated in patients with severe hepatic or renal impairment.

Directions:

Administer No-shpa Solution for Injections via intramuscular or slow intravenous injection. The injection should be given slowly to minimize the risk of adverse effects.

Scientific Evidence:

No-shpa (Drotaverine) is a widely used antispasmodic agent that acts by inhibiting phosphodiesterase enzyme and calcium influx, leading to smooth muscle relaxation. Several studies have demonstrated the efficacy of Drotaverine in relieving smooth muscle spasms with a favorable safety profile.

Additional Information:

In clinical trials, Drotaverine has shown comparable effectiveness to other antispasmodic agents like Mebeverine and Hyoscine butylbromide. Its rapid onset of action and minimal side effects make it a preferred choice in the management of acute spasmodic pain.

Drotaverine’s mechanism of action involves direct relaxation of smooth muscles without affecting normal gut motility, making it a valuable option in conditions like irritable bowel syndrome and colicky pain.

Research published in the Journal of Pain Research highlighted the efficacy of Drotaverine in reducing pain intensity and frequency of spasms in patients with irritable bowel syndrome, emphasizing its role in improving quality of life for individuals suffering from gastrointestinal spasms.