Description

Norvask (amlodipine besylate) tablets 10 mg. №30

Ingredients

Active ingredient: Amlodipine besylate 10 mg.
Inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide.

Dosage

Dosage: The recommended dose is one tablet once daily. It can be taken with or without food.

Indications

Indications: Norvask is indicated for the treatment of hypertension and chronic stable angina. It may be used alone or in combination with other antihypertensive agents.

Contraindications

Contraindications: Norvask is contraindicated in patients with a known sensitivity to dihydropyridines, amlodipine, or any inactive ingredient in the formulation.

Directions

Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. Follow the instructions of your healthcare provider.

Scientific Evidence

Amlodipine, the active ingredient in Norvask, is a dihydropyridine calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle cells, leading to vasodilation and decreased peripheral vascular resistance. This mechanism of action helps in lowering blood pressure and improving blood flow to the heart muscle.

Studies have shown the efficacy of amlodipine in the treatment of hypertension and angina. A meta-analysis published in the Journal of Hypertension concluded that amlodipine is effective in reducing blood pressure and has a good tolerability profile compared to other antihypertensive agents.

Additional Information

Norvask should be used with caution in patients with severe hepatic impairment. It may interact with certain medications, so inform your healthcare provider about all the drugs you are taking. Monitor blood pressure regularly while on Norvask therapy.

In conclusion, Norvask (amlodipine besylate) tablets 10 mg. are a well-established treatment option for hypertension and angina. With its proven efficacy and tolerability, it is a commonly prescribed medication in clinical practice. Always follow the dosage instructions and consult your healthcare provider for personalized advice on its use.