Description

Orcerin (diacerein) capsules 50 mg. №30

Ingredients:

Each Orcerin capsule contains 50 mg of diacerein as the active ingredient.

Dosage:

The recommended dosage of Orcerin is one 50 mg capsule taken orally once daily with a meal.

Indications:

Orcerin is indicated for the treatment of osteoarthritis to reduce pain and improve joint function.

Contraindications:

Do not use Orcerin if you are allergic to diacerein or have a history of inflammatory bowel disease.

Directions:

Swallow the Orcerin capsule whole with a full glass of water. Do not crush or chew the capsule.

Scientific Evidence:

Diacerein, the active ingredient in Orcerin, has been extensively studied for its efficacy in the treatment of osteoarthritis. Research has shown that diacerein helps to inhibit the production of interleukin-1 beta, a key mediator of joint inflammation and cartilage degradation in osteoarthritis.

A double-blind, placebo-controlled study published in the Journal of Rheumatology demonstrated that diacerein significantly reduced pain and improved physical function in patients with knee osteoarthritis compared to placebo.

Additional Information:

• Orcerin may take several weeks to show its full effect. It is important to continue taking the medication as prescribed.
• Common side effects of Orcerin include diarrhea, abdominal pain, and skin rash. If any severe side effects occur, discontinue use and consult a healthcare provider.

Pharmacological Effects:

Diacerein exerts its pharmacological action by inhibiting the production of pro-inflammatory cytokines, thereby reducing inflammation and slowing down the progression of osteoarthritis. It also stimulates the production of glycosaminoglycans and collagen in the cartilage, promoting joint repair and maintenance.

Clinical Trials and Comparative Effectiveness:

In a comparative study published in Osteoarthritis and Cartilage, diacerein was found to be as effective as celecoxib, a commonly used NSAID, in reducing pain and improving joint function in patients with knee osteoarthritis. The study concluded that diacerein could be a valuable treatment option for osteoarthritis with a favorable safety profile.

Another clinical trial published in Current Medical Research and Opinion showed that diacerein provided sustained pain relief and functional improvement in patients with hip osteoarthritis over a 3-month period, with a low incidence of gastrointestinal side effects compared to NSAIDs.