Description
Ortofen (Diclofenac) Enteric Tablets 0.025 g. №30
Ingredients
- Active ingredient: Diclofenac sodium 0.025 g per tablet.
Dosage
- Dosage: The usual dose is 1 tablet taken 2-3 times daily with food. Do not exceed the recommended dosage.
Indications
- Indications: Ortofen tablets are indicated for the relief of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout.
Contraindications
- Contraindications: Do not use Ortofen tablets if you have a history of allergic reactions to diclofenac or other NSAIDs, active peptic ulcer, severe heart failure, or during the third trimester of pregnancy.
Directions
- Directions: Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.
Scientific Evidence
Ortofen (diclofenac) has been extensively studied for its efficacy in managing pain and inflammation. Research has shown that diclofenac is effective in reducing pain intensity and improving physical function in patients with osteoarthritis. A meta-analysis supports the use of diclofenac for the treatment of various inflammatory conditions.
Additional Information
- It is important to note that Ortofen tablets are enteric-coated to help protect the stomach from potential irritation. However, like all NSAIDs, diclofenac can still carry risks of gastrointestinal bleeding, cardiovascular events, and renal impairment.
Pharmacological Effects
- Diclofenac works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins which are responsible for pain and inflammation. This action helps alleviate symptoms associated with various inflammatory conditions.
Clinical Trials
- Clinical trials have demonstrated the effectiveness of diclofenac in providing symptomatic relief in patients with rheumatic diseases. Diclofenac was well-tolerated and significantly improved pain and joint stiffness in patients with osteoarthritis.
