Description
Oxaliplatin Concentrate for Infusions 5 mg/ml. 30 ml. (100 mg.) №1
Ingredients:
- Oxaliplatin concentrate for infusions contains 5 mg of oxaliplatin per milliliter.
- Other ingredients may include water for injections and sodium hydroxide for pH adjustment.
Dosage:
For adults, the typical dosage of Oxaliplatin concentrate for infusions is calculated based on body surface area and is administered intravenously over a specified period as directed by a healthcare provider.
Indications:
Oxaliplatin concentrate for infusions is indicated for the treatment of advanced colorectal cancer in combination with other chemotherapy agents.
Contraindications:
Patients with a history of allergic reactions to platinum-containing compounds should not use Oxaliplatin concentrate for infusions. It is also contraindicated in patients with pre-existing severe renal impairment.
Directions:
Prior to administration, Oxaliplatin concentrate for infusions should be diluted in 250-500 ml of 5% dextrose solution and infused through a central line to minimize the risk of vein irritation.
Scientific Evidence:
Studies have shown that Oxaliplatin concentrate for infusions in combination with other chemotherapy agents has demonstrated efficacy in improving progression-free survival and overall survival rates in patients with advanced colorectal cancer.
Additional Information:
It is important to monitor patients receiving Oxaliplatin concentrate for infusions for signs of neurotoxicity, including peripheral neuropathy, and adjust the dosage or discontinue treatment if necessary to manage side effects.
- The pharmacological effects of oxaliplatin involve the formation of platinum-DNA adducts, leading to DNA damage and cell death in rapidly dividing cancer cells.
- This mechanism of action makes it an effective cytotoxic agent against colorectal cancer.
- Clinical trials have compared the effectiveness of oxaliplatin with other platinum-based chemotherapy drugs and have shown it to be equally or more effective in certain cancer types, with a more favorable side effect profile in some cases.
