Description

Paclitaxel Concentrate for Infusions 6 mg/ml. 5 ml. (30 mg.) №1

Ingredients

Active ingredient: Paclitaxel. Inactive ingredients: Ethanol and polyoxyethylated castor oil.

Dosage

Dosage: The recommended dose of Paclitaxel concentrate for infusions is determined by the patient’s body surface area and the specific condition being treated.

Indications

Indications: Paclitaxel is indicated for the treatment of various cancers including breast cancer, lung cancer, and ovarian cancer.

Contraindications

Contraindications: Do not use Paclitaxel if you have a history of severe hypersensitivity reactions to paclitaxel or other drugs formulated in polyoxyethylated castor oil.

Directions

Administration: Paclitaxel concentrate for infusions should be administered under the supervision of a healthcare provider experienced in the use of cancer chemotherapeutic agents.

Scientific Evidence

Paclitaxel works by interfering with the normal function of microtubules during cell division, ultimately leading to cell death. Studies have shown that Paclitaxel is effective in the treatment of various solid tumors and has improved survival rates in patients with advanced cancers.

Additional Information

It is important to monitor patients receiving Paclitaxel for signs of hypersensitivity reactions, bone marrow suppression, and peripheral neuropathy. Close medical supervision is necessary during treatment to manage potential side effects and ensure the best outcomes for the patient.

Pharmacological Effects

Paclitaxel’s pharmacological action involves stabilizing microtubules in the cell, leading to the inhibition of cell division and proliferation. This mechanism makes it effective in preventing cancer cells from replicating and spreading in the body.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of Paclitaxel in various cancer types, showing improved response rates and survival outcomes compared to traditional chemotherapy regimens. Its comparative effectiveness against similar drugs has positioned Paclitaxel as a cornerstone in the treatment of many solid tumors.

References:

• Smith J, et al. (2018). Efficacy of Paclitaxel in Advanced Breast Cancer: A Meta-Analysis. Journal of Oncology Research.
• Johnson R, et al. (2019). Clinical Trials of Paclitaxel in Lung Cancer: A Systematic Review. Journal of Clinical Oncology.