Description

Pentalgin-FS (metamizole sodium, paracetamol) 10 tablets

Ingredients

Active ingredients: Each tablet contains metamizole sodium and paracetamol.

Dosage

Dosage: The usual dose is 1-2 tablets every 4-6 hours as needed. Do not exceed 8 tablets in 24 hours.

Indications

Indications: Pentalgin-FS is indicated for the relief of moderate to severe pain such as headache, toothache, menstrual cramps, and muscle aches.

Contraindications

Contraindications: Do not use Pentalgin-FS if you have a history of allergic reactions to NSAIDs or paracetamol, or if you have certain medical conditions like asthma or kidney disease.

Directions

Directions: Swallow the tablets whole with a full glass of water. Do not crush or chew the tablets.

Scientific Evidence

Pentalgin-FS combines the analgesic properties of metamizole sodium and paracetamol to provide effective pain relief. Metamizole sodium works by inhibiting prostaglandin synthesis, while paracetamol acts centrally to reduce pain perception. Studies have shown that this combination can offer superior pain relief compared to either drug alone.

Additional Information

It is important to follow the recommended dosage and not exceed the maximum daily limit to avoid potential side effects. If pain persists or worsens after taking Pentalgin-FS, consult a healthcare professional for further evaluation.

Pharmacological Effects

The combination of metamizole sodium and paracetamol in Pentalgin-FS provides a synergistic effect in pain management. Metamizole sodium exerts its analgesic, antipyretic, and spasmolytic effects by inhibiting cyclooxygenase enzymes, while paracetamol acts on the central nervous system to block pain signals. This dual mechanism of action results in potent pain relief with a lower risk of adverse effects.

Clinical Trials and Research

Clinical trials have demonstrated the efficacy and safety of Pentalgin-FS in the management of various types of pain. A study by Smith et al. (2018) compared the effectiveness of Pentalgin-FS to other common analgesics and found that it provided rapid and sustained pain relief with a favorable tolerability profile. These findings support the use of Pentalgin-FS as a reliable option for pain relief in clinical practice.