Description
Pentalgin-FS (Metamizole Sodium, Paracetamol) 10 Tablets
Ingredients
- Each tablet contains metamizole sodium and paracetamol.
Dosage
- The usual dose is 1-2 tablets every 4-6 hours as needed.
- Do not exceed 8 tablets in 24 hours.
Indications
- Pentalgin-FS is indicated for the relief of moderate to severe pain such as headache, toothache, menstrual cramps, and muscle aches.
Contraindications
- Do not use Pentalgin-FS if you have a history of allergic reactions to NSAIDs or paracetamol.
- Avoid if you have certain medical conditions like asthma or kidney disease.
Directions
- Swallow the tablets whole with a full glass of water.
- Do not crush or chew the tablets.
Scientific Evidence
Pentalgin-FS combines the analgesic properties of metamizole sodium and paracetamol to provide effective pain relief. Metamizole sodium inhibits prostaglandin synthesis, while paracetamol reduces pain perception centrally. Studies suggest superior pain relief with this combination compared to either drug alone.
Additional Information
Follow the recommended dosage to avoid potential side effects. If pain persists, seek further evaluation from a healthcare professional.
Pharmacological Effects
The synergistic effect of metamizole sodium and paracetamol in Pentalgin-FS provides potent pain relief. Metamizole sodium inhibits cyclooxygenase enzymes for analgesic, antipyretic, and spasmolytic effects, while paracetamol blocks pain signals in the central nervous system, reducing adverse effects.
Clinical Trials and Research
Clinical trials support the efficacy and safety of Pentalgin-FS in pain management. Research comparing it to other analgesics found rapid and sustained pain relief with favorable tolerability, making Pentalgin-FS a reliable option for pain relief.
