Description

Pentoxifillin (Pentoxifylline) Tablets 0.1 g №30

Ingredients:

Each tablet contains 0.1 g of Pentoxifylline as the active ingredient.

Dosage:

The usual dose is one tablet three times a day with meals.

Indications:

Pentoxifylline is indicated for the treatment of peripheral vascular diseases. It helps improve blood flow by decreasing its viscosity, thereby enhancing oxygen delivery to tissues.

Contraindications:

Do not use Pentoxifylline if you have had recent bleeding in the brain or eyes. It is also contraindicated in individuals with hypersensitivity to the drug.

Directions:

Take Pentoxifylline exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage without medical supervision.

Scientific Evidence:

Pentoxifylline’s efficacy in peripheral vascular diseases is supported by various studies. Research published in the Journal of Vascular Surgery demonstrated that Pentoxifylline significantly improved walking distance in patients with intermittent claudication, a common symptom of peripheral artery disease.

Additional Information:

It is important to note that Pentoxifylline may interact with certain medications, such as anticoagulants, and should be used cautiously in patients with bleeding disorders. Consult your healthcare provider before starting Pentoxifylline therapy.

Pharmacological Effects:

Pentoxifylline exerts its pharmacological action by inhibiting phosphodiesterase and adenosine uptake, leading to increased red blood cell flexibility and decreased blood viscosity. This mechanism improves microcirculation and tissue perfusion, especially in areas with compromised blood flow.

Clinical Trials and Comparative Effectiveness:

Clinical trials have shown that Pentoxifylline is effective in improving symptoms and increasing walking distance in patients with peripheral artery disease when compared to placebo. Additionally, compared to other vasodilators, Pentoxifylline has shown comparable efficacy with a more favorable side effect profile.

Investigating the comparative effectiveness of Pentoxifylline against similar drugs in real-world settings can provide valuable insights into its clinical utility and patient outcomes.