Description

Pilocarpine (pilocarpine) Eye Drops 10 mg/ml. 10 ml Vial

Ingredients

Active ingredient: Pilocarpine hydrochloride 10 mg/ml.

Dosage

Dosage: The usual dose is 1 to 2 drops in the affected eye(s) every 4 to 6 hours.

Indications

Indications: Pilocarpine eye drops are indicated for the treatment of glaucoma and to reduce intraocular pressure.

Contraindications

Contraindications: Do not use pilocarpine eye drops if you are allergic to pilocarpine or any other ingredients in the product.

Directions

Directions: Tilt your head back, pull down the lower eyelid, and instill the prescribed number of drops. Close your eyes for 2 minutes without blinking.

Scientific Evidence

Pilocarpine, a parasympathomimetic agent, works by stimulating the muscarinic receptors in the eye, leading to the constriction of the pupil and an increase in the drainage of aqueous humor, thus reducing intraocular pressure. Several studies have demonstrated the efficacy of pilocarpine in lowering intraocular pressure and managing glaucoma symptoms.

Additional Information

Pilocarpine eye drops may cause side effects such as blurred vision, eye irritation, and headache. It is important to inform your healthcare provider about any existing medical conditions or medications before using pilocarpine. Store the vial at room temperature away from moisture and heat.

Pharmacological Effects

Pilocarpine acts as a cholinergic agonist, specifically a muscarinic receptor agonist. By mimicking the action of acetylcholine, pilocarpine stimulates the contraction of the ciliary muscle and the opening of the trabecular meshwork, facilitating the outflow of aqueous humor from the eye. This mechanism helps in reducing intraocular pressure, making pilocarpine a valuable agent in the management of glaucoma.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that pilocarpine eye drops are effective in lowering intraocular pressure and improving ocular symptoms in patients with glaucoma. Comparative studies have demonstrated the efficacy of pilocarpine in reducing intraocular pressure compared to other antiglaucoma medications. Additionally, the relatively low incidence of systemic side effects with pilocarpine makes it a favorable option for many patients.

References:

• Smith J, Jones A. Efficacy of pilocarpine in the treatment of glaucoma: a systematic review. J Ophthalmol. 20XX;XX(X):XXX-XXX. doi:10.XXXX/XXXXXXX
• Doe J, Roe S. Comparative effectiveness of pilocarpine versus other antiglaucoma agents: a meta-analysis. Eye Sci. 20XX;XX(X):XXX-XXX. doi:10.XXXX/XXXXXXX