Polcortolon (ramipril) tablets 4 mg. №50

Description

Polcortolon Composition and release form
Active ingredient: triamcinolone (4 mg).
Polcortolone is produced in the form of tablets.

Pharmacological properties
It is a hormonal agent for systemic use. Shows anti-inflammatory, antipruritic, anti-allergic action. The pharmacological action is based on the regulation of the synthesis of specific body proteins that provide the body’s response to stress (inhibits the release of interleukins, interferon gamma from lymphocytes, macrophages). Inhibits the release of inflammatory mediators by eosinophils, stabilizes the membranes of mast cells.

Indications
Polcortolon is used:

• for allergic conditions (allergic rhinitis, asthma, atopic or contact dermatitis, serum sickness, drug reactions, angioedema);
• with rheumatic diseases (severe rheumatoid arthritis, acute gout, acute nonspecific ankylosing spondylitis, bursitis, epicondylitis, post-traumatic osteoarthritis, psoriatic arthritis, synovitis, osteoarthritis);
• with dermatological diseases (severe polymorphic erythema, bullous dermatitis, exfoliative dermatitis, severe psoriasis, severe seborrheic dermatitis, eczema, atopic dermatitis, discoid lupus, contact dermatitis, alopecia areata, pemphigus);
• with eye diseases (severe allergic, inflammatory conditions);
• with endocrine diseases (adrenocortical insufficiency, Addison’s disease);
• with diseases of the respiratory tract (aspiration pneumonitis, beryllium disease, Leffler’s syndrome);
• with other diseases (polymorphic sclerosis, tuberculous meningitis).

Contraindications
Polcortolone is not used:

• with intolerance to the components;
• with systemic infections (except for the use of specific antibiotic therapy);
• with chronic primary hemorrhagic diathesis caused by insufficiency of the platelet hemostasis (Wergolf’s disease);
• with a history of GCS-induced proximal myopathy.

Application during pregnancy and lactation
The drug is used only when necessary.
Application during pregnancy can lead to fetal abnormalities, intrauterine growth retardation.
If necessary, breastfeeding is discontinued.

Method of administration and dosage
Polcortolon is administered orally.
The dose depends on the type and severity of the pathology.
The prescribed dose is administered once a day (preferably in the morning).
The standard dose is 4-32 mg. After achieving the desired effect, the dose is gradually reduced.

Overdose
Signs: development of Cushing’s syndrome, anxiety, depression, gastrointestinal colic, bleeding, arterial hypertension, ecchymosis, hyperglycemia.

Side effects:

• Digestive disorders: gastric bleeding, intestinal bleeding, perforation, pancreatitis, esophagitis, peptic ulcer, dry mouth.
• Laboratory abnormalities: negative nitrogen balance, hypercholesterolemia, hypokalemia, hypokalemic alkalosis, hypocalcemia, lymphopenia, leukocytosis, monocytopenia.
• Cardiovascular disorders: heart failure, arterial hypertension, edema, cardiac arrhythmia, necrotizing vasculitis / lymphangitis, obliterating endarteritis, thrombophlebitis.
• Neurological disorders: mental disorders, dizziness, seizures, headache, intracranial hypertension, loss of consciousness, neuritis, paresthesia.
• Ophthalmic disorders: cataract, exophthalmos, papilla edema, glaucoma, corneal ulcer, posterior subcapsular cataract, increased intraocular pressure, thinning of the cornea / sclera, exacerbation of viral / fungal diseases of the eye.
• Dermatological disorders: dermatitis, folliculitis, burning, acne, contact dermatitis, thinning of the skin, dryness, erythema, increased sweating, hirsutism, diaper rash, skin atrophy, itching, hypopigmentation, striae, irritation, telangiectasia, delayed wound healing.
• Musculoskeletal disorders: aseptic necrosis, growth retardation in children, osteoporosis, steroid myopathy, osteonecrosis, muscle weakness, loss of muscle mass, aseptic necrosis of the femur / humeral head, compression fractures of the spine, long bones, spontaneous tendon ruptures.
• Immune disorders: allergic reactions (urticaria, angioedema, burning, tingling at the injection site, hot flashes, chills, headache, hypotension, nausea, lethargy, anxiety, chest tightness, tachycardia, ringing in the ears, vomiting, paresthesia, breathing with wheezing, anaphylaxis).
• Endocrine disorders: suppression of adrenal function, stunting of children, Cushing’s syndrome, worsening of diabetes mellitus, hypoglycemia, dys- / amenorrhea, increased body weight, increased appetite, negative nitrogenous, calcium balance.
• Mental disorders: insomnia, euphoria, depression, seizures, affective disorders, mania, delirium, complications of schizophrenia, hallucinations, behavioral disorders, fear, irritability, cognitive dysfunction, amnesia, confusion.
• Infections: activation of latent infections, opportunistic infections, septic necrosis.
• General disorders: skin atrophy, local skin discoloration, fever, rhinitis, conjunctivitis.

Storage conditions and periods
Store Polcortolone for no more than three years at temperatures up to +25 ° C.