Description

Potenciale (sildenafil citrate) coated tablets 0.05 g. №2

Ingredients

Active ingredient: Each tablet contains 0.05 g of sildenafil citrate. Other inactive ingredients include [list inactive ingredients here].

Dosage

Dosage: The recommended dose is one tablet taken orally as needed, approximately 30 minutes before sexual activity. Do not exceed one tablet in a 24-hour period.

Indications

Indications: Potenciale tablets are indicated for the treatment of erectile dysfunction in adult males.

Contraindications

Contraindications: Do not use Potenciale if you are taking nitrates for chest pain or heart problems. Consult your healthcare provider before using this medication if you have a history of heart conditions or high/low blood pressure.

Directions

Directions: Swallow the tablet whole with a glass of water. Avoid consuming grapefruit or grapefruit juice while taking Potenciale, as it may increase the risk of side effects.

Scientific Evidence

Potenciale, containing sildenafil citrate, has been extensively studied for its efficacy in treating erectile dysfunction. Research published in the International Journal of Impotence Research has shown that sildenafil citrate is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which plays a crucial role in the erectile response.

Additional Information

It is important to note that Potenciale should not be used by individuals with known hypersensitivity to sildenafil or any of the tablet’s components. If you experience any adverse reactions or prolonged erections lasting more than 4 hours, seek immediate medical attention.

Pharmacological Effects

Sildenafil citrate, the active ingredient in Potenciale, works by inhibiting the enzyme PDE5, which is responsible for the degradation of cGMP in the corpus cavernosum of the penis. By inhibiting PDE5, sildenafil citrate enhances the effects of nitric oxide released during sexual stimulation, leading to smooth muscle relaxation and increased blood flow in the penile arteries, ultimately resulting in an erection.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the effectiveness of sildenafil citrate in improving erectile function and overall sexual satisfaction in men with erectile dysfunction. In a comparative study published in the Journal of Sexual Medicine, sildenafil citrate was found to be more effective than placebo in achieving and maintaining erections sufficient for satisfactory sexual intercourse.

Investigating the pharmacokinetics and pharmacodynamics of sildenafil citrate, a study in the British Journal of Clinical Pharmacology highlighted the rapid onset of action and prolonged duration of effect of the medication, making it a valuable treatment option for erectile dysfunction.

Overall, the scientific evidence and clinical trials support the efficacy and safety of Potenciale (sildenafil citrate) coated tablets 0.05 g. №2 in the management of erectile dysfunction.