Description

Pramipex (pramipexole) tablets 1 mg. №30

Ingredients

Active ingredient: Pramipexole 1 mg

Dosage

Dosage: The usual starting dose is 0.125 mg taken once daily 2-3 hours before bedtime. The dose may be gradually increased every 5-7 days.

Indications

Indications: Pramipex is indicated for the treatment of Parkinson’s disease and Restless Legs Syndrome (RLS).

Contraindications

Contraindications: Do not use Pramipex if you are allergic to pramipexole or any other ingredients in the tablet.

Directions

Directions: Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.

Scientific Evidence

Pramipexole, the active ingredient in Pramipex tablets, is a dopamine agonist that works by stimulating dopamine receptors in the brain. Studies have shown that pramipexole is effective in improving motor symptoms in patients with Parkinson’s disease and reducing symptoms of Restless Legs Syndrome.

Additional Information

It is important to follow the prescribed dosage and schedule when taking Pramipex tablets. Common side effects may include nausea, dizziness, and drowsiness. Consult your healthcare provider if you experience any severe side effects or have any concerns about the medication.

Pharmacological Effects

Pramipexole is a non-ergot dopamine agonist that directly stimulates dopamine receptors in the striatum. By mimicking the action of dopamine, pramipexole helps to improve motor function in Parkinson’s disease and alleviate symptoms of Restless Legs Syndrome. Its precise mechanism of action involves activation of dopamine D2 and D3 receptors, leading to improved motor control and symptom relief.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of pramipexole in improving motor symptoms and quality of life in patients with Parkinson’s disease. Compared to other dopamine agonists, pramipexole has shown similar efficacy but with a lower risk of motor complications and dyskinesias. Its once-daily dosing regimen also offers convenience and improved adherence compared to other medications.

Overall, Pramipex (pramipexole) tablets 1 mg. №30 offer a well-established treatment option for Parkinson’s disease and Restless Legs Syndrome, supported by scientific evidence and clinical trials showcasing its efficacy and tolerability.