Description

Pregabalin (Pregabalin) Capsules 150 mg. №21

Ingredients

Active ingredient: Pregabalin 150 mg.
Other ingredients: lactose monohydrate, maize starch, talc, gelatin, titanium dioxide (E171), and coloring agents.

Dosage

Dosage: The usual dose is 150 mg daily, divided into two or three doses. Your doctor may adjust the dosage based on your condition.

Indications

Indications: Pregabalin is used to treat neuropathic pain, fibromyalgia, and certain types of seizures. It works by reducing the abnormal electrical activity in the brain.

Contraindications

Contraindications: Do not use pregabalin if you are allergic to it or have heart problems. Consult your doctor before taking this medication.

Directions

Directions: Take pregabalin capsules orally with or without food as directed by your doctor. Do not stop taking the medication abruptly.

Scientific Evidence

Pregabalin has been extensively studied for its efficacy in treating neuropathic pain and fibromyalgia. Research published in the Journal of Pain Research has shown that pregabalin significantly reduces pain intensity and improves quality of life in patients with neuropathic pain. Clinical trials have also demonstrated the effectiveness of pregabalin in reducing the symptoms of fibromyalgia.

Additional Information

It is important to follow your doctor’s instructions carefully when taking pregabalin. Some common side effects may include dizziness, drowsiness, and weight gain. Inform your doctor if you experience any severe side effects or allergic reactions while taking this medication.

Pharmacological Effects

Pregabalin exerts its pharmacological effects by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of neurotransmitters such as glutamate, norepinephrine, and substance P, which are involved in pain signaling. By modulating these neurotransmitters, pregabalin helps to dampen the abnormal electrical activity that contributes to neuropathic pain and seizures.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that pregabalin is effective in the management of neuropathic pain, fibromyalgia, and certain types of seizures. In comparative studies, pregabalin has demonstrated similar or superior efficacy compared to other antiepileptic drugs and analgesics. A study published in the European Journal of Pain found pregabalin to be more effective than placebo in reducing pain intensity and improving sleep quality in patients with fibromyalgia.

Overall, the scientific evidence supports the use of pregabalin as a valuable treatment option for neuropathic pain, fibromyalgia, and certain types of seizures. Consult your healthcare provider for personalized advice and dosage recommendations based on your individual needs.