Description

Prenesa (perindopril tert-butylamine) tablets 4 mg. №30

Ingredients

Active ingredient: Perindopril tert-butylamine 4 mg.

Dosage

Dosage: The usual dose is 4 mg once a day. Your doctor may adjust the dose according to your condition.

Indications

Indications: Prenesa is indicated for the treatment of hypertension and heart failure.

Contraindications

Contraindications: Do not use Prenesa if you are allergic to perindopril or any other ACE inhibitors.

Directions

Directions: Take Prenesa exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water.

Scientific Evidence

Perindopril, the active ingredient in Prenesa, is an ACE inhibitor that works by blocking the formation of angiotensin II, a substance that narrows blood vessels and releases hormones that can raise blood pressure. Clinical trials have shown that perindopril is effective in reducing blood pressure and improving heart function in patients with hypertension and heart failure.

Additional Information

It is important to regularly monitor your blood pressure while taking Prenesa to ensure it is within the normal range. Inform your doctor about any side effects or concerns you may have. Avoid alcohol while taking Prenesa as it can further lower your blood pressure.

Pharmacological Effects

Perindopril exerts its pharmacological effects by inhibiting the angiotensin-converting enzyme (ACE), leading to vasodilation and reduced aldosterone secretion. This results in decreased peripheral resistance, lower blood pressure, and improved cardiac output. Additionally, perindopril has been shown to have cardioprotective effects beyond its blood pressure-lowering properties, making it a valuable option in the management of cardiovascular diseases.

Clinical Trials and Research

Clinical studies have demonstrated the efficacy of perindopril in reducing cardiovascular events and mortality in patients with coronary artery disease and heart failure. The landmark EUROPA trial showed a significant reduction in the risk of cardiovascular events with perindopril treatment, highlighting its role in secondary prevention. Furthermore, the PREAMI trial indicated the benefits of perindopril in improving endothelial function and reducing inflammation, further supporting its use in cardiovascular conditions.