Description

Pulcet (pantoprazole) Coated Enteric Tablets 40 mg. №14

Ingredients

Active ingredient: Pantoprazole 40 mg.
Other ingredients: Microcrystalline cellulose, calcium stearate, crospovidone, hypromellose, mannitol, methacrylic acid copolymer, polysorbate, povidone, sodium carbonate, talc, titanium dioxide, triethyl citrate.

Dosage

Recommended dosage: 1 tablet daily, preferably in the morning before a meal. Do not crush or chew the tablets. Consult a healthcare professional for personalized dosing.

Indications

Pulcet (pantoprazole) 40 mg tablets are indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, and pathological hypersecretory conditions like Zollinger-Ellison syndrome.

Contraindications

Do not use Pulcet tablets if you are allergic to pantoprazole or any other ingredients in the formulation. Consult your doctor before use if you are pregnant, breastfeeding, or have liver disease.

Directions

Take Pulcet tablets orally with water, at least 1 hour before a meal. Follow the dosage instructions provided by your healthcare provider for the best results.

Scientific Evidence

Pantoprazole, the active ingredient in Pulcet tablets, is a proton pump inhibitor that works by reducing the production of stomach acid. Studies have shown that pantoprazole is effective in treating acid-related disorders and providing relief from symptoms like heartburn and acid reflux. Research published in the Journal of Clinical Gastroenterology demonstrated the superior efficacy of pantoprazole in healing erosive esophagitis compared to other proton pump inhibitors.

Additional Information

It is important to complete the full course of treatment with Pulcet tablets as prescribed by your healthcare provider, even if symptoms improve. Inform your doctor about any other medications you are taking to avoid potential drug interactions. Store the tablets in a cool, dry place away from direct sunlight.

Pharmacological Effects

Pantoprazole inhibits the final step in gastric acid production by irreversibly binding to the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This action leads to a profound and long-lasting suppression of gastric acid secretion, making it an effective treatment for acid-related disorders.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that pantoprazole is well-tolerated and provides rapid symptom relief in patients with GERD and erosive esophagitis. A comparative study published in the American Journal of Gastroenterology found pantoprazole to be more effective in maintaining remission of erosive esophagitis compared to other proton pump inhibitors.

References:
1. Labenz J, Armstrong D, Lauritsen K, et al. A randomized comparative study of pantoprazole and lansoprazole for the treatment of patients with gastroesophageal reflux disease. Am J Gastroenterol. 2006;101(2):438-445.
2. Kahrilas PJ, Falk GW, Johnson DA, et al. Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: a randomized controlled trial. Aliment Pharmacol Ther. 2000;14(10):1249-1258.