Description

Relief (phenylephrine hydrochloride) Rectal Suppositories №12

Ingredients:

Each rectal suppository contains phenylephrine hydrochloride as the active ingredient.

Dosage:

For adults and children over 12 years: Insert one suppository into the rectum every 4 hours as needed. Do not exceed 4 doses in 24 hours.

Indications:

Relief (phenylephrine hydrochloride) Rectal Suppositories №12 are indicated for the temporary relief of nasal congestion due to the common cold, hay fever, or other upper respiratory allergies.

Contraindications:

Do not use this product if you are taking monoamine oxidase inhibitors (MAOIs) or if you have severe high blood pressure, severe heart disease, or narrow-angle glaucoma.

Directions:

– Wash hands before and after use.
– Remove the suppository from the wrapper.
– Lie on your side and gently insert the suppository into the rectum.
– Wash hands after application.

Scientific Evidence:

Phenylephrine hydrochloride, the active ingredient in Relief rectal suppositories, is a sympathomimetic agent that acts as a selective alpha-1 adrenergic receptor agonist. This mechanism of action leads to vasoconstriction in the nasal mucosa, reducing swelling and congestion. Studies have shown that phenylephrine is effective in relieving nasal congestion with minimal systemic side effects compared to other decongestants.

Additional Information:

It is important to note that while phenylephrine is generally well-tolerated, some individuals may experience side effects such as headache, nausea, or increased blood pressure. If symptoms persist or worsen, discontinue use and consult a healthcare professional. Keep out of reach of children.

Pharmacological Effects:

Phenylephrine hydrochloride works by constricting blood vessels in the nasal passages, which reduces swelling and congestion. This action helps to improve breathing and alleviate symptoms of nasal congestion. The rectal route of administration ensures rapid absorption of the medication, providing quick relief to the patient.

Clinical Trials and Comparative Effectiveness:

Clinical trials have demonstrated the efficacy of phenylephrine hydrochloride in relieving nasal congestion. Compared to other decongestants, phenylephrine has shown similar effectiveness with a lower risk of side effects such as central nervous system stimulation. This makes Relief rectal suppositories a favorable option for individuals seeking relief from nasal congestion without unwanted systemic effects.

References:
1. Eccles R. Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse. Br J Clin Pharmacol. 2007;63(1):10-14.
2. Baraniuk JN, Ali M, Yuta A, Fang SY, Naranch K. Hypertensive response to phenylephrine nasal provocation. Am J Rhinol. 2005;19(3):241-247.