Relief Ultra (hydrocortisone acetate, zinc sulfate monohydrate) rectal suppositories №12

Description

Relief Ultra (hydrocortisone acetate, zinc sulfate monohydrate) rectal suppositories №12

Composition

active substances: hydrocortisone acetate, zinc sulfate monohydrate;

1 suppository contains hydrocortisone acetate 10 mg, zinc sulfate monohydrate 11 mg;

excipients: methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), calcium hydrogen phosphate, cocoa butter, magnesium stearate.

Medicinal form

Rectal suppositories.

Main physicochemical properties: opaque suppositories from pale white to light yellow in the shape of a torpedo.

Pharmacotherapeutic group

Means for the treatment of hemorrhoids and anal fissures for local use.
ATX code C05A A.

Pharmacological properties

Hydrocortisone acetate is a glucocorticosteroid, with local application it has anti-inflammatory, anti-allergic, vasoconstrictor and anti-pruritic effects. Suppresses the release of inflammatory mediators, blocks the metabolism of arachidonic acid.

Zinc sulfate monohydrate helps heal wounds and erosions, normalizes skin hydration.

Indications

This drug Relief Ultra suppositories is used to treat diseases in proctology, in particular:

• external and internal hemorrhoids;
• cracks, fistulas;
• ulcers, erosions of the perianal region and rectum, which are accompanied by severe inflammatory manifestations;
• proctitis, anal itching;
• eczema, dermatitis of the perianal region.

Contraindications

The drug Relief Ultra suppositories in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or one of the auxiliary components.
Also contraindicated for:

• specific (bacterial, fungal, viral, tuberculous) lesions of the anorectal region;
• neoplasms in the anus;
• thromboembolic disease;
• intestinal obstruction;
• abscesses, risk of perforation;
• peritonitis;
• fistulas, fresh intestinal anastomoses or fistulous passages.

Use with caution while treating with anticoagulants, hypoglycemic agents, barbiturates, diuretics, cardiac glycosides.
When used simultaneously with other GCS (both topical and oral), the likelihood of systemic effects may increase.

Application during pregnancy and lactation

The use of strong / very strong GCS topically during pregnancy may be associated with placental insufficiency and low birth weight. Therefore, this drug is contraindicated in the treatment of pregnant women.
If it is necessary to use the drug, if a woman is lactating, then breastfeeding should be suspended for the duration of treatment.

Method of administration and dosage

Designed for use in proctology.

Pre-wash the skin around the anus with cool water, clean the affected area with a moistened soft cloth, dry it carefully with toilet paper or a soft cloth. Before the introduction of the suppository, it is necessary to remove the protective plastic sheath from it.

Insert the suppository into the anus as deeply as possible. Inject one suppository 2 to 4 times a day (at night, in the morning and after each bowel movement). The duration of the course of treatment should not exceed 7 days.
The correction of the duration of treatment, dosages and treatment regimens is determined by the attending physician individually, depending on the individual indicators of the course of the disease.

Overdose

Overdose for a long period can cause hypercortisolism.

Long-term use in large doses enhances resorption and increases the risk of developing systemic effects of hydrocortisone, such as menstrual irregularities, increased blood pressure, delayed wound healing, muscle weakness, insomnia, increased blood sugar, hirsutism, glaucoma, etc.

If accidentally swallowed, gastrointestinal disorders (nausea, stomach pain) may occur.

Side effects

The drug is usually well tolerated. In cases of hypersensitivity, reactions such as:

• nausea, vomiting, diarrhea;
• rash, dermatitis, allergic urticaria;
• hyperemia, swelling, itching, atrophic skin changes, hypertrichosis;
• Cushing’s syndrome, hyperglycemia, glucosuria, growth retardation, intracranial hypertension;
• rosace-like and perioral dermatitis, with or without skin atrophy;
• the “rebound” effect, which can cause steroid dependence;
• delayed wound healing;
• depigmentation, hypertrichosis.