Rifampicin capsules 150 mg №20

Description

Rifampicin capsules 150 mg №20

Composition

active ingredient: rifampicin;

1 capsule contains 150 mg of rifampicin (in terms of 100% dry matter);

excipients: light magnesium carbonate, lactose monohydrate, calcium stearate.

The composition of the cap and body of the capsule includes dyes Sunset Yellow FCF (E 110), Ponceau 4R (E 124) and titanium dioxide (E 171).

Dosage form

Capsules.

basic physico-chemical properties: hard capsules with a cap and a body of orange-red color, which contain a powder or mass in the form of a partially or fully formed column from pale red to brown-red with white patches.

Pharmacological group

Anti-tuberculosis drugs. Antibiotics.
ATX code J04A B02.

Indications Rifampicin 

An antibiotic that is mainly used to treat tuberculosis of various organs. It is also effective for the treatment of various forms of leprosy, inflammatory and infectious diseases of the lower respiratory tract, which are caused by multi-resistant staphylococci, as well as osteomyelitis, urinary and biliary tract, the acute phase of gonorrhea, and other pathogens that rifampicin can counteract.
It is able to completely or partially destroy the rabies virus, rabies encephalitis, therefore it is actively used in the incubation treatment of these diseases. Shows activity against gram-positive (staphylococci) and gram-negative (menningococci, gonococci) cocci.
Unfortunately, microorganisms quickly develop resistance (resistance) to rifampicin, so it is advisable, if possible, not to abuse its prescription for the treatment of diseases not caused by tuberculosis.

Contraindications

Contraindicated for use in children – infants, patients with jaundice, hepatitis, kidney disease, especially if their excretory function is reduced. Not applicable in case of allergy to rifampicin.
It is contraindicated to administer the drug intravenously if the patient suffers from pulmonary heart failure or phlebitis.

Application during pregnancy and lactation

Contraindicated.

Method of administration and dosage

Rifampicin should be taken orally 30 minutes before or 2 hours after a meal with plenty of water.

Tuberculosis:

• adults should be prescribed at a dose of 8-12 mg / kg of body weight per day. Patients weighing less than 50 kg – 450 mg / day, 50 kg or more – 600 mg / day;
• children from 6 to 12 years old – 10-20 mg / kg of body weight per day; the maximum daily dose should not exceed 600 mg.

The duration of anti-tuberculosis therapy is individual, due to the therapeutic effect and can be 1 year or more. In order to avoid the development of resistance of mycobacteria to rifampicin, the drug should be prescribed, as a rule, together with other anti-tuberculosis drugs of the I and II line in their usual doses.

Infectious and inflammatory diseases of a non-tuberculous nature caused by pathogens sensitive to the drug – brucellosis, legionellosis, severe forms of staphylococcal infection (together with another appropriate antibiotic to prevent the emergence of resistant strains):

for adults, prescribe 900-1200 mg per day in 2-3 doses, the maximum daily dose is 1200 mg. After the disappearance of the symptoms of the disease, the drug should be taken for another 2-3 days.

Leprosy: the drug (in combination with immunostimulating agents) is administered orally at 600 mg per day in 1-2 doses for 3-6 months (repeated courses are possible with an interval of 1 month). According to another scheme (against the background of combined antileprosy therapy), the drug is prescribed in a daily dose of 450 mg, divided into 3 doses for 2-3 weeks with an interval of 2-3 months for 1-2 years.

Carriage of N. meningitidis: Rifampicin administered within 4 days. Daily dose for adults – 600 mg, for children – 10-12 mg / kg of body weight.

Children

The drug in this dosage form should not be used for children under 6 years of age.

Overdose

Overdose is manifested by symptoms of severe intoxication, dyspeptic symptoms, renal, hepatic failure. Tachycardia, arrhythmia, convulsions, cardiac arrest, and even death are possible. Therefore, it is necessary to conduct gastric lavage as soon as possible and prescribe symptomatic therapy.

Side effects

Intolerance reactions are rare. Possible dyspeptic disorders, disruption of the pancreas, liver, reduces pressure if too rapid intravenous administration.
Since the drug itself is painted in a bright red-brown color, urine, sputum discharge, and tears acquire the same shade.