Description

Rispetril (Risperidone) Coated Tablets 4 mg. №60 Vial

Ingredients

Active ingredient: Risperidone 4 mg.
Other ingredients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide, macrogol.

Dosage

Dosage: The usual starting dose is 2 mg once daily. Dosage may be adjusted at intervals of 24 hours or more. Maximum dose is 16 mg/day.

Indications

Indicated for: Treatment of schizophrenia in adults and adolescents aged 13-17 years, and acute manic or mixed episodes associated with Bipolar I Disorder.

Contraindications

Contraindications: Hypersensitivity to risperidone or any component of the formulation. Patients with severe renal or hepatic impairment.

Directions

Directions: Swallow the tablet whole with water. Can be taken with or without food. Do not crush, chew, or break the tablet.

Scientific Evidence

Risperidone, the active ingredient in Rispetril, is an atypical antipsychotic that works by blocking dopamine and serotonin receptors in the brain. Studies have shown its efficacy in managing symptoms of schizophrenia and bipolar disorder. Research by Leucht et al. (2013) demonstrated the effectiveness of risperidone in reducing relapse rates in schizophrenia patients compared to placebo.

Additional Information

Rispetril has been well-tolerated in clinical trials with common side effects including weight gain and somnolence. It is important to monitor patients for metabolic changes and movement disorders while on risperidone therapy. Consult a healthcare provider for personalized recommendations.

Pharmacological Effects: Risperidone acts by antagonizing dopamine and serotonin receptors in the brain, leading to a reduction in psychotic symptoms. It also has a moderate affinity for adrenergic and histaminergic receptors, contributing to its pharmacological effects.

Clinical Trials: In a comparative effectiveness study by Stroup et al. (2015), risperidone was found to be as effective as other atypical antipsychotics in the treatment of schizophrenia, with similar rates of symptom improvement and tolerability.