$65.00
Manufacturer: Canada
Treatment of schizophrenia; treatment of moderate to severe manic episodes in bipolar disorders; treatment of severe aggression in patients with dementia of the Alzheimer’s type from moderate to severe degree when there is a threat of harming oneself or others and when there is no response to non-pharmacological methods of treatment; symptomatic treatment of severe aggression in behavioral disorders in children over 5 years of age and adolescents with below-average mental development or mental retardation diagnosed according to DSM-IV criteria, in which the severity of aggressive or other destructive behavior requires pharmacological treatment.
Description
Rispetril (risperidone) oral solution 1 mg/ml. 30 ml. vial
Composition
active substance: risperidone;
1 ml of solution contains 1 mg of risperidone;
excipients: purified water, benzoic acid (E 210), tartaric acid, sodium hydroxide, sorbitol solution (E 420).
Medicinal form
Oral solution.
Main physicochemical properties: transparent, odorless liquid.
Pharmacotherapeutic group
Antipsychotic drugs.
ATX code N05A X08.
Pharmacological properties
Risperidone is a selective monoaminergic antagonist. It shows high affinity for serotonergic 5-HT2 and dopaminergic D2 receptors. Risperidone also binds to α1-adrenergic receptors and, with lower affinity, to H1-histaminergic and α2-adrenergic receptors. Risperidone does not show affinity for cholinergic receptors. Although risperidone is a potent D2-antagonist, which has been attributed to its efficacy on the productive symptoms of schizophrenia, it does not cause a significant inhibition of motor activity and induces catalepsy to a lesser extent compared to classical antipsychotics. Balanced central antagonism with respect to serotonin and dopamine reduces susceptibility to extrapyramidal side effects and extends the therapeutic effect of the drug to include negative and affective symptoms of schizophrenia.
Pharmacological properties
Rispetril solution is an antipsychotic drug (neuroleptic). The active substance selectively (selectively) blocks 5-HT2-serotonergic, D2-dopaminergic receptors of the central nervous system, as well as α1-adrenergic, to a lesser extent, α2-adrenergic and H1-histamine receptors. Eliminates hallucinations, delusions, automatism, reduces aggressiveness, fear.
Indications
Rispetril solution is used:
- with schizophrenia with pronounced productive (aggressiveness, delirium, hallucinations, thought disorders) or negative symptoms (poor speech, social and emotional detachment);
- in acute / chronic psychoses with pronounced productive or negative symptoms;
- in other psychotic conditions with affective symptoms.
Contraindications
Rispetril solution does not apply:
- if you are allergic to risperidone;
- with intolerance to excipients.
Application during pregnancy and lactation
Contraindicated.
Method of administration and dosage
Rispetril solution is used internally.
The standard dose for adults is 2 mg / day, on the next day the dose is increased to 4 mg / day, on the 3rd day – up to 6 mg / day in one or two doses. In the future, an individual maintenance dose is selected (usually 4–8 mg / day).
The maximum dose is 16 mg / day.
Elderly patients or patients with severe hepatic / renal impairment should be halved.
Overdose
Symptoms: drowsiness, excessive sedation, tachycardia, extrapyramidal disturbances, instability of blood pressure.
Therapeutic measures: gastric lavage, the appointment of sorbents, support of the respiratory and cardiovascular systems, control of electrolyte balance, regulation of the acid-base state.
Side effects:
- Neurological disorders: hyperthermia of central origin, drowsiness, headache, fainting, confusion, akathisia, extrapyramidal disorders (hypokinesia, akinesia, tremor, muscle rigidity), sleep disturbances, insomnia, depression, seizures, neuroleptic malignant syndrome (shortness of breath) tachypnea, convulsions, tachycardia, arrhythmia, unstable blood pressure, hyperthermia, increased sweating, severe muscle stiffness, involuntary urination, pallor of the skin, fatigue, weakness), tardive dyskinesia.
- Cardiovascular disorders: decrease / increase in blood pressure (including orthostatic hypotension), reflex tachycardia, hypertension, stroke.
- Digestive disorders: constipation, abdominal pain, vomiting, dysphagia, nausea.
- Dermatological disorders: hyperpigmentation, xeroderma, photosensitivity.
- Endocrine disorders: hyperglycemia, hyperprolactinemia, galactorrhea, dysmenorrhea, gynecomastia, amenorrhea.
- Genitourinary disorders: priapism, anorgasmia, erectile dysfunction, ejaculation, dysuria, urinary incontinence, polyuria.
- Hematological disorders: neutro-, thrombocytopenia, thrombocytopenic purpura, anemia.
- Ophthalmic disorders: violation of accommodation, xerophthalmia, decreased visual acuity.
- Others: peripheral edema, weight gain, rhinitis, manifestations of allergies, incl. angioedema, skin rashes, pain in joints / bones / muscles.
Recent Reviews