Rozamet (metronidazole) cream 1% 25 g. tube

Description

Rozamet (metronidazole) cream 1% 25 g. tube

Composition

active substance: metronidazole;

1 g of cream contains 10 mg of metronidazole;

auxiliary substances: methylparaben (methylparahydroxybenzoate) (E218), propylparaben (propylparahydroxybenzoate) (E216), glycerin, mineral oil, anionic emulsified wax, propylene glycol, purified water.

Medicinal form

Cream.

Main physicochemical properties: uniform white cream.

Pharmacotherapeutic group

Chemotherapeutic agents for local use.
ATX code D06B X01.

Pharmacological properties

It is an antimicrobial agent used in dermatology. The effectiveness is ensured by the presence of metronidazole in this drug, which is 5-nitroimidazole. The mechanism of its action is due to the ability to interact with deoxyribonucleic acid (DNA) of cells of microorganisms. In this case, the production of nucleic acids is inhibited and bacteria die. Active against protozoa: Entamoeba histolytica, Trichomonas vaginalis, Giardia lamblia, as well as facultative anaerobes Bacteroides spp. (Bacteroides ovatus, Bacteroides fragilis, Bacteroides distasonis, Bacteroides thetaiotaomіcron, Bacteroides vulgaris), Prevotella spp. (Prevotella buccae, Prevotella bivia, Prevotella disiens), Fusobacterium spp., Veіllonella spp., Some facultative obligate (Clostrіdium spp.), Facultative (Eubacterіum spp., Peptococcus spp., Peptostrobate. Gardnerella vaginalis. Aerobes are insensitive to metronidazole, but in the presence of mixed flora (anaerobes + aerobes), it acts synergistically with antibiotics.

Indications

Rozamet is prescribed for the local treatment of rosacea, rosacea-like steroid dermatitis, acne vulgaris, skin infections, bedsores, burns, eczema, seborrheic eczema, oily seborrhea, seborrheic dermatitis, trophic ulcers (with varicose veins, diabetes mellitus), wounds that slowly heal, hemorrhoids, cracks in the anus, balanoposthitis, vulvovaginitis.

Contraindications

Rozamet cannot be prescribed:

• if you are allergic to metronidazole, nitroimidazole derivatives;
• with intolerance to auxiliary components;
• during pregnancy;
• during lactation;
• children under 18.

It is used with caution in blood diseases, leukopenia, in diseases of the central nervous system (for example, epilepsy), in liver failure.

Application during pregnancy and lactation

This medication is contraindicated during pregnancy.
The active ingredient is able to penetrate into breast milk, therefore, breastfeeding during the treatment period should be canceled. You can resume feeding no earlier than 48 hours after the end of the use of this medication.

Method of administration and dosage

Rozamet is used for external use only.

The cream is applied to cleansed skin in a thin layer and rub in lightly 1-2 times / day.
The duration of treatment depends on the indications.

Overdose

Overdose symptoms with Rosamet: leukopenia, vomiting, abdominal pain, neuropathy, diarrhea, impaired coordination, paresthesia, metallic taste in the mouth, dizziness, convulsions.
Treatment: discontinuation, maintenance therapy.

Side effects:

• Digestive upsets: dry mouth, nausea, change in taste, metallic taste, abdominal cramping, loss of appetite, constipation or diarrhea.
• Local reactions: irritation, pain, itching, burning.
• Neurological disorders: headache, dizziness.
• Hematopoiesis changes: leukopenia, leukocytosis.
• Allergic reactions: itching of the skin, urticaria, rash.

There may be a reddish-brown staining of urine.