Description

Sandimmun Neoral (cyclosporin) soft capsules 25 mg. №50

Ingredients

Active ingredient: Each soft capsule contains 25 mg of cyclosporin.

Dosage

Dosage: The dosage of Sandimmun Neoral (cyclosporin) soft capsules should be individualized according to the patient’s weight and clinical condition. It is important to follow the prescribed dosage and administration instructions provided by the healthcare provider.

Indications

Indications: Sandimmun Neoral (cyclosporin) soft capsules are indicated for the prevention of organ rejection in kidney, liver, and heart transplant patients. It is also used in the treatment of severe cases of psoriasis and rheumatoid arthritis.

Contraindications

Contraindications: This medication is contraindicated in patients with a hypersensitivity to cyclosporin or any of the ingredients in the formulation. It should not be used in patients with uncontrolled hypertension or malignancies.

Directions

Directions: Take Sandimmun Neoral (cyclosporin) soft capsules exactly as prescribed by your healthcare provider. Swallow the capsules whole with a full glass of water. Do not crush or chew the capsules.

Scientific Evidence

Cyclosporin, the active ingredient in Sandimmun Neoral, exerts its immunosuppressive effects by inhibiting the production of interleukin-2 and other cytokines that are crucial for T-cell activation. This mechanism of action makes it a valuable medication in preventing organ rejection post-transplantation and managing autoimmune conditions.

Several studies have demonstrated the efficacy of Sandimmun Neoral in improving transplant outcomes and reducing the incidence of rejection episodes. A study by Kahan et al. (1999) showed that cyclosporin-based immunosuppression resulted in superior graft survival rates compared to other regimens.

Additional Information

In addition to its immunosuppressive properties, cyclosporin has been investigated for its potential in treating various dermatological conditions, such as psoriasis. The drug’s ability to modulate the immune response has shown promising results in controlling the hyperproliferative skin changes characteristic of psoriasis.

It is essential to monitor patients receiving Sandimmun Neoral for signs of nephrotoxicity, hypertension, and other potential adverse effects associated with long-term immunosuppressive therapy. Regular monitoring of blood levels and renal function is crucial to ensure the drug’s efficacy and safety.