Sargin (L-arginini hydrochloridum) solution for infusion 42 mg/ml. 100 ml. vial

Description

Sargin (L-arginini hydrochloridum) solution for infusion 42 mg/ml. 100 ml. vial

Composition

active ingredient: L-arginini hydrochloridum;

1 ml of solution contains L-arginine hydrochloride 42 mg;

excipient: water for injection.

Dosage form

Solution for infusion.

Basic physical and chemical properties: clear, colorless or slightly yellowish-brown liquid.

Pharmacological group

Blood substitutes and perfusion solutions. Additional solutions for administration. Amino acids. Arginine hydrochloride.
Code ATX B05X B01.

Pharmacological properties

Arginine (a-amino-d-guanidinovaleric acid) is an amino acid that belongs to the class of conditionally essential amino acids and is an active and versatile cellular regulator of numerous vital functions of the body, exhibiting protective effects that are important in a critical state of the body.

Sargin exhibits antihypoxic, membrane stabilizing, cytoprotective, antioxidant, antiradical, detoxifying activity, acts as an active regulator of intermediate metabolism and energy supply processes, plays a certain role in maintaining hormonal balance in the body. It is known that arginine increases the blood levels of insulin, glucagon, growth hormone and prolactin, participates in the synthesis of proline, polyamine, agmatine, is involved in the processes of fibrinogenolysis, spermatogenesis, and has a membrane-depolarizing effect.

Arginine is one of the main substrates in the urea synthesis cycle in the liver. The hypoammoniemic effect of the drug is realized by activating the conversion of ammonia into urea. It has a hepatoprotective effect due to antioxidant, antihypoxic and membrane stabilizing activity, positively affects the processes of energy supply in hepatocytes.

Indications

Sargin solution is used:

• with atherosclerosis of the vessels of the heart, brain, peripheral vessels;
• with diabetic angiopathy;
• with ischemic heart disease;
• with angina pectoris;
• after suffering an acute myocardial infarction, cerebrovascular accident;
• with chronic heart failure;
• with arterial hypertension;
• with hypercholesterolemia;
• with COPD;
• with interstitial pneumonia;
• with idiopathic pulmonary hypertension;
• with chronic postembolic pulmonary hypertension;
• in hypoxic conditions;
• with acute / chronic hepatitis of various etiologies;
• with hyperammonemia;
• with asthenic conditions;
• with a decrease in the function of the thymus gland;
• during the period of convalescence after infectious diseases, surgical interventions;
• with delayed fetal development;
• with preeclampsia.

Contraindications

Sargin solution is not used:

• with intolerance to the components;
• with a history of allergic reactions;
• with hypochloremic acidosis;
• with severe renal impairment;
• when taking potassium-sparing diuretics, spironolactone;
• children under three years old.

Application during pregnancy and lactation

It is applied.

Method of administration and dosage

Sargin solution is administered intravenously.
The rate of administration is 10 drops / minute during the first 10-15 minutes, then the rate of administration is allowed to increase to 30 drops / minute.
The standard daily dose is 100 ml, with severe circulatory disorders, pronounced symptoms of intoxication, asthenic conditions, hypoxia – 200 ml.
The standard dose for children under 12 years of age is 5-10 ml / kg.

Overdose

Symptoms: hypoglycemia, renal dysfunction, metabolic acidosis.
Treatment: the infusion is stopped, the vital functions of the body are monitored and maintained.
If necessary, saluretics, electrolyte solutions are administered.

Side effects:

• Digestive disorders: nausea, dry mouth, vomiting.
• Immune disorders: rash, urticaria, angioedema.
• General disorders: feeling of heat, pyrexia, body aches.
• Changes at the injection site: itching, hyperemia, pallor of the skin, cyanosis.
• Musculoskeletal disorders: joint pain.
• Cardiovascular disorders: fluctuations in blood pressure, pain in the region of the heart, changes in heart rate.
• Neurological disorders: headache, fear, dizziness, weakness, tremors, convulsions.
• Laboratory changes: hyperkalemia.