Description

Septipim (cefepime) powder for solution for injections 1000 mg. №1 vial

Ingredients

Active ingredient: Cefepime. Inactive ingredients may include lactose, sodium carbonate, or other excipients.

Dosage

Dosage: The usual adult dose is 1 to 2 grams every 12 hours, depending on the severity of the infection. Dosage adjustments may be necessary in patients with renal impairment.

Indications

Indications: Septicemia, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, skin and skin structure infections, and gynecological infections.

Contraindications

Contraindications: Hypersensitivity to cefepime or other cephalosporins.

Directions

Administration: Administer by intravenous infusion over 30 minutes. Follow reconstitution and dilution instructions carefully.

Scientific Evidence

Cefepime, the active ingredient in Septipim, is a fourth-generation cephalosporin with broad-spectrum antibacterial activity. Studies have shown its efficacy in treating various infections, including those caused by multidrug-resistant pathogens. Research by Livermore et al. (2002) demonstrated the potency of cefepime against extended-spectrum beta-lactamase-producing bacteria.

Additional Information

It is important to monitor renal function during cefepime therapy, especially in elderly patients. Adverse effects may include diarrhea, nausea, and hypersensitivity reactions. Consult healthcare professionals for personalized recommendations.

Cefepime exerts its pharmacological action by inhibiting bacterial cell wall synthesis, leading to cell death. Its extended spectrum of activity covers a wide range of Gram-positive and Gram-negative bacteria, making it a valuable option in the treatment of severe infections.

Comparative studies have shown cefepime to be as effective as other broad-spectrum antibiotics with a lower risk of resistance development. Its ability to penetrate tissues and maintain high concentrations at the infection site contributes to its clinical efficacy.