Description

Signicef (Levofloxacin) Eye Drops 0.5%, 5 ml Vial

Ingredients

Active ingredient: Levofloxacin 0.5%
Other ingredients: Benzalkonium chloride, sodium chloride, sodium hydroxide, and water for injection.

Dosage

Dosage: Instill 1 to 2 drops into the affected eye(s) every 2 hours for the first 2 days, then 4 times daily for the next 5 days.
Do not touch the tip of the dropper to prevent contamination.

Indications

Indications: Signicef eye drops are indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of microorganisms.

Contraindications

Contraindications: Do not use in patients with a history of hypersensitivity to levofloxacin or other quinolones.

Directions

Directions: Wash hands before use. Tilt your head back, pull down the lower eyelid, and instill the prescribed number of drops. Close the eye for a few minutes to allow absorption.

Scientific Evidence

Levofloxacin, the active ingredient in Signicef eye drops, is a fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Studies have shown its efficacy in treating bacterial conjunctivitis by inhibiting bacterial DNA gyrase, thereby disrupting DNA replication and transcription.

Additional Information

Signicef eye drops should be stored at room temperature away from moisture and heat. Do not freeze. Contact lenses should be removed before application and can be reinserted 15 minutes after administration.

Pharmacological Effects: Levofloxacin exerts its pharmacological action by interfering with the enzymes necessary for DNA replication in bacteria, leading to cell death. This mechanism makes it effective against a wide range of gram-positive and gram-negative bacteria.

Clinical Trials: Clinical trials have demonstrated the efficacy of levofloxacin in the treatment of bacterial conjunctivitis, showing rapid resolution of symptoms and eradication of the causative pathogens. Comparative studies have also highlighted its effectiveness compared to other antibiotics commonly used in ophthalmic infections.