Description

Sodiofolin (Disodium Folinate) Solution for Injections or Infusions 100 mg. 50 mg/ml. 2 ml. №1 Vial

Ingredients:

Each vial contains 100 mg of disodium folinate in a 2 ml solution.

Dosage:

The recommended dosage is determined by a healthcare provider based on individual needs. It is typically administered via injection or infusion.

Indications:

Sodiofolin is indicated for use as a rescue therapy in combination with high-dose methotrexate in the treatment of osteosarcoma. It is also used in the management of accidental overdosage of folic acid antagonists.

Contraindications:

Do not use Sodiofolin in patients with known hypersensitivity to folinic acid or any component of the formulation. Caution is advised in patients with renal impairment.

Directions:

Sodiofolin should be administered under the supervision of a healthcare professional experienced in the use of folinic acid. The solution is for intravenous or intramuscular use only.

Scientific Evidence:

Sodiofolin has been extensively studied in clinical trials for its efficacy and safety. Research has shown that folinic acid plays a crucial role in enhancing the efficacy of methotrexate while reducing its toxic effects.

A study published in the Journal of Clinical Oncology demonstrated the benefits of using Sodiofolin in osteosarcoma patients undergoing high-dose methotrexate therapy. The addition of folinic acid resulted in improved outcomes and reduced treatment-related toxicities.

Additional Information:

It is important to monitor folate levels during Sodiofolin therapy to ensure optimal treatment outcomes. Adverse reactions may include allergic reactions, nausea, and vomiting. Patients should be closely monitored for any signs of toxicity.

Consult with a healthcare provider for personalized dosing recommendations and to discuss any potential drug interactions. Proper storage of the vials is essential to maintain the stability of the solution.