Description

Sodiofolin (Disodium Folinate) Solution for Injections or Infusions

Ingredients:

• Each vial contains 100 mg of disodium folinate in a 2 ml solution.

Dosage:

• The recommended dosage is determined by a healthcare provider based on individual needs. It is typically administered via injection or infusion.

Indications:

• Sodiofolin is indicated for use as a rescue therapy in combination with high-dose methotrexate in the treatment of osteosarcoma.
• It is also used in the management of accidental overdosage of folic acid antagonists.

Contraindications:

• Do not use Sodiofolin in patients with known hypersensitivity to folinic acid or any component of the formulation.
• Caution is advised in patients with renal impairment.

Directions:

• Sodiofolin should be administered under the supervision of a healthcare professional experienced in the use of folinic acid.
• The solution is for intravenous or intramuscular use only.

Scientific Evidence:

• Sodiofolin has been extensively studied in clinical trials for its efficacy and safety.
• Research has shown that folinic acid plays a crucial role in enhancing the efficacy of methotrexate while reducing its toxic effects.
• A study published in the Journal of Clinical Oncology demonstrated the benefits of using Sodiofolin in osteosarcoma patients undergoing high-dose methotrexate therapy.
• The addition of folinic acid resulted in improved outcomes and reduced treatment-related toxicities.

Additional Information:

• It is important to monitor folate levels during Sodiofolin therapy to ensure optimal treatment outcomes.
• Adverse reactions may include allergic reactions, nausea, and vomiting.
• Patients should be closely monitored for any signs of toxicity.
• Consult with a healthcare provider for personalized dosing recommendations and to discuss any potential drug interactions.
• Proper storage of the vials is essential to maintain the stability of the solution.