Sorbifer Durules (iron sulfate, ascorbic acid) XR №50 vial

Description

Sorbifer Durules (iron sulfate, ascorbic acid) coated tablets with modified release №50 vial

Composition

active ingredients: iron sulfate, ascorbic acid;

1 tablet contains: 320 mg of anhydrous iron sulfate (corresponding to 100 mg of ferrous iron), 60 mg of ascorbic acid;

excipients: povidone, polyethylene powder, carbomers, magnesium stearate;

shell composition: hypromelose, macrogols, titanium dioxide (E 171), iron oxide yellow (E 172), paraffin.

Dosage form

Coated tablets with modified release.

Basic physical and chemical properties:

Lenticular, slightly biconvex, ocher-yellow film-coated tablets, debossed with “Z” on one side, with a characteristic odor.

Pharmacological group

Antianemic agents. Iron preparations, various combinations.
ATX code B03A E10.

Pharmacological properties

Iron sulfate compensates for the lack of iron in the body. As part of the protoporphyrin prosthetic group of hemoglobin, iron(II) plays an important role in the binding and transport of oxygen and carbon dioxide.

As part of the protoporphyrin group of cytochrome enzymes, iron plays a key role in the processes of electron transport. In these processes, the absorption and release of electrons is carried out by reverse transformation (Fe(II) <–––> Fe(III).

A large amount of iron can also be found in muscle myoglobin molecules.

Vitamin C increases the absorption of iron in the intestine and is involved in redox processes.

Indications

Sorbifer Durules tablets is a medicine used for anemia. Replenishes the lack of iron in the body, which plays an important role in the transport and binding of oxygen, carbon dioxide. Vitamin C, which is part of the composition, increases the absorption of iron in the intestine, participates in redox processes.
Sorbifer durules tablets is used to prevent / treat iron deficiency anemia.

Contraindications

Sorbifer Durules tablets should not be used:

• with allergies to components;
• with stenosis (narrowing) of the esophagus, other obstructive gastrointestinal diseases;
• with intestinal diverticulum;
• with intestinal obstruction;
• in conditions accompanied by the accumulation of iron (hemochromatosis, hemosiderosis);
• with repeated blood transfusion;
• in case of violation of the mechanisms of iron inclusion in hemoglobin (for example, in case of lead poisoning);
• with sideroachrestic anemia;
• with thrombosis, a tendency to thrombosis;
• with thrombophlebitis;
• with severe kidney disease;
• with the simultaneous use of parenteral forms of iron;
• with other types of anemia, not due to iron deficiency (caused by a lack of vitamin B12, hemolytic anemia);
• with a disorder of the mechanisms of iron excretion (thalassemia);
• with diabetes mellitus;
• with urolithiasis;
• with fructose intolerance;
• up to 12 years old.

Application during pregnancy and lactation

Allowed.

Method of administration and dosage

The Sorbifer Durules tablets should be swallowed whole, without chewing, with a glass of water, at least 30 minutes before meals.
For the prevention of anemia – 1 tablet / day.
For the treatment of anemia – 1 tablet x 2 times / day.
In case of side effects, it is recommended to reduce the dose to 1 tablet / day.
During pregnancy: during the first 6 months, the recommended dose is 1 tablet / day, in the third trimester, as well as during lactation – 1 tablet x 2 times / day.
The duration of admission depends on the individual results of the iron content in the blood. After normalization of the results of the blood test (hemoglobin level), the use of the drug should be continued until the iron stores are saturated (2 months). With iron deficiency anemia, the average duration of therapy is 3–6 months.

Overdose

Symptoms: abdominal pain, vomiting, loose stools, bloody stools, drowsiness, shock, dehydration, metabolic acidosis, tachycardia, hyperglycemia, arterial hypotension.
In severe cases – blood clotting disorders, vascular insufficiency, hyperthermia, hypoglycemia, hepatic / renal failure, convulsions, coma, perforation of the gastrointestinal tract, cirrhosis, pyloric stenosis.
Overdose treatment: drink milk, rinse the stomach, then introduce 50-100 ml of water with the addition of deferoxamine. In case of severe poisoning (iron level> 90 μmol / L – in children,> 142 μmol / L – in adults), intensive therapy should be started, deferoxamine should be used.

Side effects

Possible nausea, diarrhea / constipation, esophageal ulcers, stomach pain, esophageal stenosis, heartburn, allergic reactions (anaphylaxis, pruritus, skin redness, Quincke’s edema), damage to the glomerular system of the kidneys, formation of urate / cystine / oxalate stones, crystalluria, damage to insular apparatus (glucosuria, hyperglycemia), diabetes mellitus, increased blood pressure, myocardial dystrophy, thrombocytosis, neutrophilic leukocytosis, erythrocytopenia, hyperprothrombinemia, erythrocyte hemolysis, sleep disturbances, excitability, headache, impaired metabolism of copper, zinc.