Streptomycin (streptomycin) powder for solution for injection 0.5 g. №1 vial

Description

Streptomycin (streptomycin) powder for solution for injection 0.5 g. №1 vial

Composition

active substance: streptomycin;

1 vial contains streptomycin sulfate sterile in terms of streptomycin 0.5 or 1 g

Dosage form

Powder for solution for injection.

Basic physical and chemical properties: white or almost white powder.

Pharmacotherapeutic group

Antimicrobials for systemic use. Aminoglycosides.
ATX code J01G A01.

Pharmacological properties

This medicine is classified by experts as antimicrobial agents for the treatment of tuberculosis.

Indication

Treatment of newly diagnosed pulmonary tuberculosis and tuberculous lesions of other organs. Patients who have been previously treated, the drug should be prescribed after laboratory detection of sensitivity to it isolated from the patient mycobacteria.

Infectious and inflammatory processes of different locations caused by gram-positive and gram-negative microorganisms sensitive to the drug: pneumonia caused by Klebsiella, endocarditis, plague, tularemia, brucellosis.

Contraindications

You can not use the drug for those who have: botulism, cardiovascular insufficiency, diseases of the vestibular and hearing aids, myasthenia gravis, cerebrovascular accident, sensitivity to the composition of the drug, a tendency to bleeding, renal failure.

Pregnancy and breastfeeding period

Before using the drug, it is imperative that you go to the doctor and pay attention to the composition of this drug. If its ingredients do not harm the health of your baby and your health, then you can use the medication.

Method of application and dosage

Streptomycin powder for solution should be administered intramuscularly, in the form of aerosols, intratracheally. Adults can also use the drug intracavernously.

When administered intramuscularly, the single dose for adults is 0.5-1 g, the highest daily dose is 2 g. For patients weighing less than 50 kg and people over 60 years of age, the daily dose usually does not exceed 0.75 g.

Daily dose for children aged 1-3 months – 10 mg / kg body weight, 3-6 months – 15 mg / kg, from 6 months to 2 years – 20 mg / kg. The daily dose for children aged 2 years to 18 years should be determined at the rate of 15-20 mg / kg body weight, but not more than 0.5 g per day for children (up to 12 years) and not more than 1 g per day for adolescents (12-18 years).

In the treatment of tuberculosis, the daily dose should usually be administered once. With poor tolerability of the drug, the daily dose can be divided into 2 injections. The duration of treatment depends on the form and phase of the disease and is 2-3 months.

In the treatment of infections of non-tuberculous etiology, the daily dose should be administered in 3-4 doses with an interval of 6-8 hours. The duration of treatment is 7-10 days (should not exceed 14 days).

For intramuscular administration, the drug Streptomycin powder for solution should be dissolved in water for injections, 0.9% sodium chloride solution or 0.25-0.5% novocaine solution at the rate of 4 ml of solvent per 1 g of drug. Prepare the solution ex tempore.

Intratracheally, the drug should be administered 0.5-1 g in 5-7 ml of 0.9% sodium chloride solution or 0.5% novocaine solution 2-3 times a week.

For use in the form of aerosols for adults to administer 0.5-1 g of Streptomycin, for such administration the drug should be dissolved in 4-5 ml (for thermal inhalation – in 25-100 ml) of 0.9% sodium chloride solution. Children over 1 month of age should be given the same route of administration as intramuscular administration. Depending on the indications, other Streptomycin-compatible drugs may be included in the inhalation solution.

Intracavernous drug Streptomycin powder for solution is administered by insufflation in the form of fine powder or instillation of 10% solution (solvent – 0.9% sodium chloride solution) in a surgical hospital 1 time per day in a total dose of not more than 1 g, regardless of the number of cavities and route of administration.

In patients with hypertension and coronary heart disease, treatment with the drug, regardless of the route of administration, begin with reduced (up to 0.25 g) doses. With good tolerability, the dose can be increased to normal.

Children

The drug should be used in children over 1 month of age. Streptomycin should be prescribed to children under 2 years of age only for vital indications.

Overdose

Patients inadvertently used this drug to a greater extent than recommended by the attending physician and, at the same time, they had such symptoms of the body’s response to the drug: increased side effects, and respiratory arrest may also occur.

Adverse reactions

Situations with patients who had adverse reactions were recorded and the following symptoms were observed: peripheral nephritis, vomiting, headache, hyperemia, hematuria, anaphylactic shock, impaired renal function, tachycardia, diarrhea, abdominal pain, nausea, myasthenia gravis , hemolytic anemia, pancytopenia, pruritus, urticaria, skin rashes, azotemia, leukopenia, drowsiness, shortness of breath, paresthesia, convulsions.