Description

Streptomycin (streptomycin) powder for solution for injection 1 g. №1 vial

Ingredients

Active ingredient: Streptomycin sulfate

Dosage

Dosage: The usual dose is **15 mg/kg** body weight given once daily or in divided doses every **12 hours**.

Indications

Indicated for: Treatment of tuberculosis, plague, tularemia, and other bacterial infections.

Contraindications

Contraindications: Hypersensitivity to streptomycin, myasthenia gravis, and severe renal impairment.

Directions

Administration: Administered by deep intramuscular injection or slow intravenous infusion.

Scientific Evidence

Streptomycin, a broad-spectrum antibiotic, has been extensively studied for its efficacy in treating various bacterial infections. Research has shown that streptomycin is particularly effective against Mycobacterium tuberculosis, the causative agent of tuberculosis. Clinical trials have demonstrated the drug’s ability to reduce the bacterial load and improve treatment outcomes in patients with drug-susceptible tuberculosis.

Additional Information

Streptomycin works by inhibiting protein synthesis in bacteria, leading to cell death. Its mechanism of action involves binding to the 30S subunit of the bacterial ribosome, disrupting the translation process. This unique mode of action makes streptomycin a valuable addition to the antibiotic armamentarium, especially in the treatment of multidrug-resistant tuberculosis strains.

Streptomycin has been compared to other first-line anti-tuberculosis drugs like isoniazid and rifampicin. While each drug has its own strengths and limitations, streptomycin plays a crucial role in combination therapy for tuberculosis, particularly in cases where resistance to other drugs is a concern. Research suggests that the use of streptomycin in combination regimens can improve treatment outcomes and reduce the risk of drug resistance development.