Sumamigren (sumatriptan) coated tablets 50 mg. №2

$9.90

Manufacturer: Poland

For rapid relief of migraine attacks, with or without aura.

Out of stock

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Description

Sumamigren (sumatriptan) coated tablets 50 mg. №2

Composition

active substance: sumatriptan;

1 tablet contains 50 mg or 100 mg of sumatriptan, corresponding to 70 mg or 140 mg of sumatriptan succinate, respectively;

excipients: lactose monohydrate; microcrystalline cellulose; croscarmellose sodium; magnesium stearate; talc; colloidal anhydrous silica;

shell: hypromellose; macrogol 6000; talc; titanium dioxide (E 171); triethyl citrate and varnish with dye cochineal red A (E 124) for tablets 50 mg.

Dosage form

Coated tablets.

Basic physical and chemical properties:

  • 50 mg: film-coated tablets, oblong, biconvex, light pink with a score line on one side;
  • 100 mg: film-coated tablets, oblong, biconvex, white.

Pharmacotherapeutic group

Drugs used to treat migraines. Selective agonist of 5HT1 serotonin receptors. Sumatriptan.
ATX code N02C C01.

Pharmacological properties

Sumatriptan is a specific selective serotonin 5-HTID receptor agonist. It does not affect other subtypes of serotonin receptors (5-HT2-5-HT7). These receptors are found mainly in the cranial blood vessels. Experimental studies have shown that sumatriptan has a selective vasoconstrictor effect on blood vessels in the carotid arteries, but does not affect cerebral circulation. The carotid artery system supplies blood to extra- and intracranial tissues, such as meninges. As a result of the expansion of these vessels, migraine develops. Additionally, experimental data have shown that sumatriptan inhibits the activity of the trigeminal nerve. These are two possible mechanisms through which the antimigraine activity of sumatriptan is detected.

The clinical response begins approximately 30 minutes after taking 100 mg orally. The recommended oral dose of sumatriptan is 50 mg, although migraine attacks vary in severity in both patients and patients.

Indications

To quickly relieve migraine attacks, with or without aura.

Contraindications

The drug Sumamigren tablets is not treated if the patient is diagnosed with ischemic heart disease, other cardiovascular pathologies, strokes, transient circulatory disorders in the brain, liver or kidney pathologies, high blood pressure that cannot be controlled by drugs, as well as during therapy with the help of monoxidase inhibitors, treatment with drugs from the ergotamine group.
Contraindicated if migraine has a hemiplegic, ophthalmoplegic or basilar etiology. Not used to treat elderly and young patients.
Use with caution if the patient has kidney or liver pathology, high blood pressure, epilepsy, a tendency to seizures, and an allergy to sulfonamides.

Application during pregnancy and lactation

Contraindicated.

Method of administration and dosage

The usual dose is 1 tablet at a dosage of 50 milligrams. You should not break the tablet in half, it will lose its therapeutic medicinal properties and will not have a therapeutic effect. With the same attack, the dose cannot be doubled, only with the next one can the dose be increased to 100 milligrams, if in the first case the drug did not have its effect.
It is permissible to apply the treatment twice a day. The maximum allowable dose per day is 300 milligrams.

Overdose

Excessive intake of the drug Sumamigren tablets can lead to an increase in the number and intensity of side effects. In this case, the patient must be admitted to a hospital. The antidote has not yet been invented, hemodialysis is ineffective. It is necessary to rinse the stomach, prescribe the intake of enterosorbents. Treatment is symptomatic.

Side effects

Taking Sumamigren tablets can cause side reactions from the circulatory system: vasoconstriction of the coronary arteries, a decrease or increase in pressure, tachycardia, bradycardia, arrhythmias, ischemia. Also frequent are dyspeptic disorders (in the form of nausea, vomiting, epigastric pain), allergic reactions (urticaria, rash, erythema, anaphylaxis).