Description

Champix (varenicline) Coated Tablets №25 (0.5 mg. №11+1 mg. №14)

Ingredients

Active ingredient: Varenicline tartrate.
Other ingredients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, Opadry White (hydroxypropyl cellulose, titanium dioxide, polyethylene glycol, talc).

Dosage

Recommended dosage: The treatment begins with a 1-week titration pack followed by the maintenance pack. The initial dose is 0.5 mg once daily for days 1-3, then 0.5 mg twice daily for days 4-7. The maintenance dose is 1 mg twice daily.

Indications

Champix (varenicline) tablets are indicated for smoking cessation. It is used to help adults quit smoking by reducing the urge to smoke and withdrawal symptoms.

Contraindications

Do not use Champix if: you are allergic to varenicline or any ingredients in the product, under 18 years old, pregnant, or breastfeeding.

Directions

Take Champix as directed by your healthcare provider. It is usually taken after eating and with a full glass of water. Follow the prescribed dosing schedule for best results.

Scientific Evidence

Varenicline, the active ingredient in Champix, works by targeting the nicotine receptors in the brain, reducing the pleasurable effects of smoking and decreasing withdrawal symptoms. Clinical trials have shown that Champix is more effective than a placebo in aiding smoking cessation. A study published in the New England Journal of Medicine found that varenicline was more effective than bupropion or nicotine replacement therapy in helping smokers quit.

Additional Information

It is important to inform your healthcare provider about your medical history and any medications you are currently taking before starting Champix. Some common side effects may include nausea, insomnia, abnormal dreams, and headache. If you experience any severe side effects, contact your doctor immediately.

Pharmacological Effects: Varenicline acts as a partial agonist at α4β2 nicotinic acetylcholine receptors, reducing the reinforcing effects of nicotine. It also acts as a full agonist at α7 nicotinic receptors, which may contribute to its smoking cessation efficacy.

Clinical Trials: Clinical studies have demonstrated the efficacy of Champix in helping smokers quit. A meta-analysis published in JAMA Internal Medicine concluded that varenicline was associated with higher long-term abstinence rates compared to placebo and other smoking cessation treatments.