Description

Champix (Varenicline) Coated Tablets

Ingredients

• Active ingredient: Varenicline tartrate
• Other ingredients: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, Opadry White (hydroxypropyl cellulose, titanium dioxide, polyethylene glycol, talc)

Dosage

Recommended dosage: The treatment starts with a 1-week titration pack followed by the maintenance pack. Initial dose: 0.5 mg once daily for days 1-3, then 0.5 mg twice daily for days 4-7. Maintenance dose: 1 mg twice daily.

Indications

Champix (Varenicline) tablets are indicated for smoking cessation to help adults quit smoking by reducing the urge to smoke and withdrawal symptoms.

Contraindications

Do not use Champix if: allergic to varenicline or any ingredients, under 18 years old, pregnant, or breastfeeding.

Directions

Take Champix as directed by your healthcare provider. Usually taken after eating with a full glass of water. Follow the dosing schedule for best results.

Scientific Evidence

Varenicline targets nicotine receptors in the brain, reducing pleasurable effects of smoking and withdrawal symptoms. Clinical trials show Champix is more effective than placebo. A study in the New England Journal of Medicine found it more effective than bupropion or nicotine replacement therapy.

Additional Information

• Pharmacological Effects: Acts as a partial agonist at α4β2 nicotinic acetylcholine receptors, reducing nicotine’s effects. Acts as a full agonist at α7 nicotinic receptors, aiding smoking cessation.
• Clinical Trials: Studies show Champix’s efficacy in helping smokers quit. A meta-analysis in JAMA Internal Medicine concluded varenicline had higher long-term abstinence rates than placebo and other treatments.