Thiogamma Turbo (α-lipoic acid) solution for infusions 1.2% 50 ml. №10 vial

Description

Thiogamma Turbo (α-lipoic acid) solution for infusions 1.2% 50 ml. №10 vial

Composition

active substance: α-lipoic acid;

50 ml of solution contain 1.2% of meglumine salt of α-lipoic acid 1167.7 mg (corresponding to 600 mg of α-lipoic acid);

Excipients: meglumine, macrogol 300, water for injections.

Dosage form

Solution for infusions.

Main physical and chemical properties: yellowish or greenish-yellow solution.

Pharmacotherapeutic group

Drugs that affect the digestive system and metabolic processes.
ATX code A16A X01.

Pharmacological properties

α-lipoic acid is a substance that is synthesized in the body and acts as a coenzyme in the oxidative decarboxylation of α-keto acids; plays an important role in the process of energy production in the cell. Helps reduce blood sugar and increase the amount of glycogen in the liver. Lack or disruption of α-lipoic acid (thioctic acid) metabolism due to intoxication or excessive accumulation of some breakdown products (eg ketone bodies) leads to disruption of aerobic glycolysis. α-lipoic acid can exist in two physiologically active forms (oxidized and reduced), which are characterized by antitoxic and antioxidant effects. α-lipoic acid affects cholesterol metabolism, participates in the regulation of lipid and carbohydrate metabolism, improves liver function (due to hepatoprotective, antioxidant, detoxifying effects). In terms of pharmacological properties, α-lipoic acid is similar to B vitamins.

Indications

Thiogamma Turbo is used in the treatment of sensory disturbances that have arisen against the background of diabetic polyneuropathy.

Contraindications

Thiogamma Turbo is not prescribed for intolerance to α-lipoic acid or other components of the drug. Its use is impossible in heart and respiratory failure, in the acute phase of myocardial infarction, acute cerebrovascular accident, dehydration, chronic alcoholism and other conditions that can cause lactic acidosis.
When Tiogama Turbo is administered, the bottle should be placed in a light-protective bag that protects the solution from light exposure.
One of the components of a successful treatment for polyneuropathy is a competent correction of blood sugar levels.
With parenteral administration of the drug, there is a high risk of developing allergic reactions, therefore, a sensitivity test must be carried out before the administration of the solution. If, during the administration of the drug, the patient experiences nausea, itching or malaise, then the treatment is canceled and measures are taken to alleviate the patient’s condition.
During therapy with Tiogama Turbo, some patients experience a short increase in sensitivity, which is caused by an increase in tissue regeneration processes.

Application during pregnancy and lactation

Thiogamma Turbo is not prescribed for lactating and pregnant women, since there is not enough clinical experience with the use of the drug during these periods.

Method of administration and dosage

Thiogamma Turbo is administered directly from the bottle at a dosage of 600 mg per day. The duration of the infusion should not be less than 30 minutes.
To maintain the effectiveness of the drug, due to the increased sensitivity of α-lipoic acid to light, the drug should be stored in its original packaging in places protected from light penetration.
Treatment begins with intravenous administration of the drug Tiogamma Turbo. The duration of treatment can vary from 2 to 4 weeks. After stabilization of the patient’s condition, they are transferred to taking medications in oral form, which contain thioctic acid.

Overdose

In case of an overdose of Thiogamma Turbo, patients may experience nausea, vomiting, abdominal pain, acute necrosis of skeletal muscles, inhibition of bone marrow hematopoiesis, psychomotor agitation and generalized convulsions. Treatment is symptomatic.

Side effects

When Tiogamma Turbo is administered, patients may complain of the development of visual impairment, double vision, headaches, excessive sweating, nausea, vomiting, abdominal pain, allergic reactions, tachycardia.